TY - JOUR
T1 - Radiation-induced capsule tissue reactions around textured breast implants in a rat model
AU - Eltze, E.
AU - Schäfer, U.
AU - Bettendorf, O.
AU - Rody, A.
AU - Herchenröder, F.
AU - Chiwritsch, T.
AU - Jackisch, C.
AU - Pfleiderer, B.
N1 - Funding Information:
This work was supported by an innovative medical research (IMF) grant of the University of Muenster, Germany (PF 229830).
PY - 2006/6
Y1 - 2006/6
N2 - Capsule fibrosis and other complications around various filled breast implants were evaluated in a rat radiation model after 12 months of implantation. Model implants, one per rat, were implanted subcutaneously. One month after subcutaneous implantation, high voltage radiation followed one half each group. A higher rate of capsule fibrosis occurred in radiated animals. Malignant tumors at the implantation site developed in 40% of radiated and 24% of non-radiated animals, with a much higher rate of mitosis in the radiated group (Mann-Whitney, P = 0.008). The presence of an implant is a cofactor for tumor development in rats (χ2-test, χ2 = 6.927; P = 0.008) as well as radiation, since none of the control animals developed tumors. Applied to humans, capsule contracture (fibrosis) is a common complication of radiation, while development of radiation-induced sarcoma is a rare complication after postoperative radiotherapy by all account. Still further long-term follow-up human studies are necessary.
AB - Capsule fibrosis and other complications around various filled breast implants were evaluated in a rat radiation model after 12 months of implantation. Model implants, one per rat, were implanted subcutaneously. One month after subcutaneous implantation, high voltage radiation followed one half each group. A higher rate of capsule fibrosis occurred in radiated animals. Malignant tumors at the implantation site developed in 40% of radiated and 24% of non-radiated animals, with a much higher rate of mitosis in the radiated group (Mann-Whitney, P = 0.008). The presence of an implant is a cofactor for tumor development in rats (χ2-test, χ2 = 6.927; P = 0.008) as well as radiation, since none of the control animals developed tumors. Applied to humans, capsule contracture (fibrosis) is a common complication of radiation, while development of radiation-induced sarcoma is a rare complication after postoperative radiotherapy by all account. Still further long-term follow-up human studies are necessary.
UR - http://www.scopus.com/inward/record.url?scp=33744531272&partnerID=8YFLogxK
U2 - 10.1016/j.breast.2005.08.037
DO - 10.1016/j.breast.2005.08.037
M3 - Journal articles
C2 - 16233977
AN - SCOPUS:33744531272
SN - 0960-9776
VL - 15
SP - 331
EP - 338
JO - Breast
JF - Breast
IS - 3
ER -
