Radiation-induced capsule tissue reactions around textured breast implants in a rat model

E. Eltze*, U. Schäfer, O. Bettendorf, A. Rody, F. Herchenröder, T. Chiwritsch, C. Jackisch, B. Pfleiderer

*Corresponding author for this work
8 Citations (Scopus)


Capsule fibrosis and other complications around various filled breast implants were evaluated in a rat radiation model after 12 months of implantation. Model implants, one per rat, were implanted subcutaneously. One month after subcutaneous implantation, high voltage radiation followed one half each group. A higher rate of capsule fibrosis occurred in radiated animals. Malignant tumors at the implantation site developed in 40% of radiated and 24% of non-radiated animals, with a much higher rate of mitosis in the radiated group (Mann-Whitney, P = 0.008). The presence of an implant is a cofactor for tumor development in rats (χ2-test, χ2 = 6.927; P = 0.008) as well as radiation, since none of the control animals developed tumors. Applied to humans, capsule contracture (fibrosis) is a common complication of radiation, while development of radiation-induced sarcoma is a rare complication after postoperative radiotherapy by all account. Still further long-term follow-up human studies are necessary.

Original languageEnglish
Issue number3
Pages (from-to)331-338
Number of pages8
Publication statusPublished - 06.2006


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