Quantitative PCR analysis of different splice forms of NFAT5 revealed specific gene expression in fetal and adult brain

Andreas Dalski; Hans Joachim Wagner; Eberhard Schwinger; Christine Zühlke

doi:10.1016/S0169-328X(00)00202-3

Quantitative PCR analysis of different splice forms of NFAT5 revealed specific gene expression in fetal and adult brain

Andreas Dalski^*, Hans Joachim Wagner, Eberhard Schwinger, Christine Zühlke

^*Corresponding author for this work

Institute of Human Genetics

13 Citations (Scopus)

Abstract

To investigate sequences or mutations associated with neurodegenerative disorders, we performed analyses for the NFAT5 gene, which is located in the candidate region for the autosomal dominantly inherited spinocerebellar ataxia type 4 (SCA4). PCR based expression analyses detected NFAT5 transcripts with alternative splicing in 27 fetal and adult human tissues. Interestingly, by using quantitative methods on cDNA from fetal and adult human brain a significant difference at the expression level for one splice form could be shown. Copyright (C) 2000 Elsevier Science B.V.

Original language	English
Journal	Molecular Brain Research
Volume	83
Issue number	1-2
Pages (from-to)	125-127
Number of pages	3
ISSN	0169-328X
DOIs	https://doi.org/10.1016/S0169-328X(00)00202-3
Publication status	Published - 10.11.2000

Funding

This work was supported by the Fritz Thyssen Stiftung [AZ1999 2060] (Köln). We would like to thank Nina Richter for excellent technical assistance.

Research Areas and Centers

Research Area: Medical Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0169-328X(00)00202-3

Cite this

@article{68e4e0d9ca6f44d38ad5aa003dc22a54,

title = "Quantitative PCR analysis of different splice forms of NFAT5 revealed specific gene expression in fetal and adult brain",

abstract = "To investigate sequences or mutations associated with neurodegenerative disorders, we performed analyses for the NFAT5 gene, which is located in the candidate region for the autosomal dominantly inherited spinocerebellar ataxia type 4 (SCA4). PCR based expression analyses detected NFAT5 transcripts with alternative splicing in 27 fetal and adult human tissues. Interestingly, by using quantitative methods on cDNA from fetal and adult human brain a significant difference at the expression level for one splice form could be shown. Copyright (C) 2000 Elsevier Science B.V.",

author = "Andreas Dalski and Wagner, \{Hans Joachim\} and Eberhard Schwinger and Christine Z{\"u}hlke",

note = "Funding Information: This work was supported by the Fritz Thyssen Stiftung [AZ1999 2060] (K{\"o}ln). We would like to thank Nina Richter for excellent technical assistance. ",

year = "2000",

month = nov,

day = "10",

doi = "10.1016/S0169-328X(00)00202-3",

language = "English",

volume = "83",

pages = "125--127",

journal = "Molecular Brain Research",

issn = "0169-328X",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Quantitative PCR analysis of different splice forms of NFAT5 revealed specific gene expression in fetal and adult brain

AU - Dalski, Andreas

AU - Wagner, Hans Joachim

AU - Schwinger, Eberhard

AU - Zühlke, Christine

N1 - Funding Information: This work was supported by the Fritz Thyssen Stiftung [AZ1999 2060] (Köln). We would like to thank Nina Richter for excellent technical assistance.

PY - 2000/11/10

Y1 - 2000/11/10

N2 - To investigate sequences or mutations associated with neurodegenerative disorders, we performed analyses for the NFAT5 gene, which is located in the candidate region for the autosomal dominantly inherited spinocerebellar ataxia type 4 (SCA4). PCR based expression analyses detected NFAT5 transcripts with alternative splicing in 27 fetal and adult human tissues. Interestingly, by using quantitative methods on cDNA from fetal and adult human brain a significant difference at the expression level for one splice form could be shown. Copyright (C) 2000 Elsevier Science B.V.

AB - To investigate sequences or mutations associated with neurodegenerative disorders, we performed analyses for the NFAT5 gene, which is located in the candidate region for the autosomal dominantly inherited spinocerebellar ataxia type 4 (SCA4). PCR based expression analyses detected NFAT5 transcripts with alternative splicing in 27 fetal and adult human tissues. Interestingly, by using quantitative methods on cDNA from fetal and adult human brain a significant difference at the expression level for one splice form could be shown. Copyright (C) 2000 Elsevier Science B.V.

UR - https://www.scopus.com/pages/publications/0034634698

U2 - 10.1016/S0169-328X(00)00202-3

DO - 10.1016/S0169-328X(00)00202-3

M3 - Journal articles

C2 - 11072102

AN - SCOPUS:0034634698

SN - 0169-328X

VL - 83

SP - 125

EP - 127

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1-2

ER -

Quantitative PCR analysis of different splice forms of NFAT5 revealed specific gene expression in fetal and adult brain

Abstract

Funding

Research Areas and Centers

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this