Quantitative EEG in long-term survivors of acute lymphoblastic leukemia

Michael A. Ueberall*, Karin Haupt, Holger Hertzberg, Thorsten Langer, Walburga Meier, Walter J. Huk, Jörn D. Beck, Dieter Wenzel

*Corresponding author for this work
8 Citations (Scopus)


Conventional and quantitative aspects of electroencephalographic recordings obtained during a follow-up surveillance study in long-term survivors of acute lymphoblastic leukemia in childhood were investigated with respect to differences in central nervous system prophylaxis given during antileukemic therapy and compared with data derived from healthy controls. Central nervous system prophylaxis consisted either of cranial irradiation (18 Gray, group A, n = 8) or intermediate high-dose methotrexate (2000 mg/m2; group B, n = 5), each combined with intrathecal methotrexate. Conventional electroencephalographic analysis revealed comparable results in all three study groups. However, quantitative electroencephalography showed significantly increased absolute power scores for all frequency bands in both long-term survivor groups. Relative power estimates revealed a significant increase in δ/τ activities in both prophylaxis groups compared to healthy controls, which were countered by decreased percentage power scores in the α-range. Quantitative electroencephalographic comparisons between both central nervous system prophylaxis groups revealed only small differences in quantity, not quality, of the observed power disturbances with slightly higher deviations in irradiated long-term survivors than in nonirradiated ones. Topographical distributions of spectral band power were comparable between all three study groups without evidence for therapy-related topographical differences.

Original languageEnglish
JournalPediatric Neurology
Issue number4
Pages (from-to)293-298
Number of pages6
Publication statusPublished - 11.1996

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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