TY - JOUR
T1 - Quality of life improvement in patients with bone metastases undergoing palliative radiotherapy
AU - Cañón, Verónica
AU - Gómez-Iturriaga, Alfonso
AU - Casquero, Francisco
AU - Rades, Dirk
AU - Navarro, Arturo
AU - Hoyo, Olga del
AU - Morillo, Virginia
AU - Willisch, Patricia
AU - López-Guerra, José Luis
AU - Illescas-Vacas, Ana
AU - Ciervide, Raquel
AU - Martinez-Indart, Lorea
AU - Cacicedo, Jon
N1 - Publisher Copyright:
© 2022. Greater Poland Cancer Centre
PY - 2022
Y1 - 2022
N2 - Background: The aim of the study was to analyze the impact of palliative radiotherapy on quality of life (QoL) in patients with symptomatic bone metastases. Materials and methods: We present the results from a prospective multicentric study including 128 patients who provided pre and post-radiotherapy (one month after treatment) brief pain inventory (BPI) assessments. Worst pain was recorded using the BPI (range: 0–10). Pain response was described according to the International Bone Metastases Consensus on palliative radiation. Regarding QoL, for each pre and post-radiation BPI-questionnaire, scores from the interference domains were summed and averaged to obtain an overall interference score. Results: There was a significant correlation between radiation treatment response and improvement in all functional interference domains except sleeping. Patients > 75 years old presented a significantly higher improvement in general activity, mood and relationships with others compared to patients ≤ 75 years old. Patients presenting a baseline pain score ≥ 8 showed a higher improvement in the general activity item (p = 0.049). There was no statistically significant association between pretreatment ECOG, chemotherapy, primary tumor location and radiation schedule with any of the functional interference items.
AB - Background: The aim of the study was to analyze the impact of palliative radiotherapy on quality of life (QoL) in patients with symptomatic bone metastases. Materials and methods: We present the results from a prospective multicentric study including 128 patients who provided pre and post-radiotherapy (one month after treatment) brief pain inventory (BPI) assessments. Worst pain was recorded using the BPI (range: 0–10). Pain response was described according to the International Bone Metastases Consensus on palliative radiation. Regarding QoL, for each pre and post-radiation BPI-questionnaire, scores from the interference domains were summed and averaged to obtain an overall interference score. Results: There was a significant correlation between radiation treatment response and improvement in all functional interference domains except sleeping. Patients > 75 years old presented a significantly higher improvement in general activity, mood and relationships with others compared to patients ≤ 75 years old. Patients presenting a baseline pain score ≥ 8 showed a higher improvement in the general activity item (p = 0.049). There was no statistically significant association between pretreatment ECOG, chemotherapy, primary tumor location and radiation schedule with any of the functional interference items.
UR - http://www.scopus.com/inward/record.url?scp=85135388919&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/b1f9d5e2-ec41-3ecb-9f6d-c614f535823c/
U2 - 10.5603/RPOR.a2022.0048
DO - 10.5603/RPOR.a2022.0048
M3 - Journal articles
AN - SCOPUS:85135388919
SN - 1507-1367
VL - 27
SP - 428
EP - 439
JO - Reports of Practical Oncology and Radiotherapy
JF - Reports of Practical Oncology and Radiotherapy
IS - 3
ER -