Abstract
Background: Psoriasis is a frequent chronic inflammatory systemic disease. It is associated with changes in the microbiome, which may trigger psoriasis and influence the course of the disease. Objective: Current methods for detection and the potential role of the microbiome in the pathogenesis of psoriasis are described. Material and methods: A literature search was conducted using the databases Medline and PubMed as well as a general internet and book research. Results: Both skin and gut microbiota are involved in the immunopathogenesis and may substantially modulate psoriasis. Antimicrobial peptides may serve as a link between the microbiome and the immunological mechanisms in psoriasis by regulating the microbiome at interfaces and can trigger psoriasis as antigens. Recent innovative methods, such as 16S rRNA next-generation sequencing significantly facilitate microbiome analysis. Conclusion: The analysis of the microbiome in patients with psoriasis before, during and after treatment provides a basis for the identification of potential biomarkers for predicting individual treatment responses and facilitating the decision for a certain treatment.
| Translated title of the contribution | Psoriasis and the microbiome |
|---|---|
| Original language | German |
| Journal | Hautarzt |
| Volume | 70 |
| Issue number | 6 |
| Pages (from-to) | 416-421 |
| Number of pages | 6 |
| ISSN | 0017-8470 |
| DOIs | |
| Publication status | Published - 01.06.2019 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
