Psoriasis und Mikrobiom

Translated title of the contribution: Psoriasis and the microbiome

M. Witte*, D. Thaçi

*Corresponding author for this work


Background: Psoriasis is a frequent chronic inflammatory systemic disease. It is associated with changes in the microbiome, which may trigger psoriasis and influence the course of the disease. Objective: Current methods for detection and the potential role of the microbiome in the pathogenesis of psoriasis are described. Material and methods: A literature search was conducted using the databases Medline and PubMed as well as a general internet and book research. Results: Both skin and gut microbiota are involved in the immunopathogenesis and may substantially modulate psoriasis. Antimicrobial peptides may serve as a link between the microbiome and the immunological mechanisms in psoriasis by regulating the microbiome at interfaces and can trigger psoriasis as antigens. Recent innovative methods, such as 16S rRNA next-generation sequencing significantly facilitate microbiome analysis. Conclusion: The analysis of the microbiome in patients with psoriasis before, during and after treatment provides a basis for the identification of potential biomarkers for predicting individual treatment responses and facilitating the decision for a certain treatment.

Translated title of the contributionPsoriasis and the microbiome
Original languageGerman
Issue number6
Pages (from-to)416-421
Number of pages6
Publication statusPublished - 01.06.2019

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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