Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain

F. Pennazio; Julius Friedemann Werner; Marco Aglietta; P. Cerello; E. Fiorina; S. Garbolino; V. Monaco; Anna Vignati; R. Wheadon; V. Ferrero; Magdalena Rafecas

doi:10.1109/NSS/MIC44845.2022.10399204

Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain

F. Pennazio^*, Julius Friedemann Werner, Marco Aglietta, P. Cerello, E. Fiorina, S. Garbolino, V. Monaco, Anna Vignati, R. Wheadon, V. Ferrero, Magdalena Rafecas

^*Corresponding author for this work

Institute of Medical Engineering

Abstract

Prompt Gamma Timing is a technique proposed for range monitoring in proton therapy. The experimental measurements so far are limited to a single secondary proton detector. In this study we present an innovative technique to merge the information from many detectors in different positions into a unique estimation of the beam particle motion in the spatiotemporal domain. We test the proposed method by means of Monte Carlo simulations, with various beam ranges and a number of primaries interesting for proton therapy monitoring (107). The method is based on the Maximum Likelihood Expectation Maximization algorithm, and we show its applicability with both MeV-range gamma detectors as well as lower energy detectors such as PET detectors. The preliminary results shown indicate a range resolution of about 5 mm. The ultimate goal of this study is to provide a robust mathematical instrument to expand the significance of Prompt Gamma Timing measurements, to be useful for the prototypes presently under construction by the treatment monitoring community.

Original language	English
DOIs	https://doi.org/10.1109/NSS/MIC44845.2022.10399204
Publication status	Published - 26.01.2024
Event	2022 IEEE Nuclear Science Symposium and Medical Imaging Conference - Milan, Italy Duration: 05.11.2022 → 12.11.2022

Conference

Conference	2022 IEEE Nuclear Science Symposium and Medical Imaging Conference
Abbreviated title	NSS/MIC
Country/Territory	Italy
City	Milan
Period	05.11.22 → 12.11.22

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure

Research Areas and Centers

Academic Focus: Biomedical Engineering

DFG Research Classification Scheme

2.22-32 Medical Physics, Biomedical Technology

Access to Document

10.1109/NSS/MIC44845.2022.10399204

Cite this

Pennazio, F., Werner, J. F., Aglietta, M., Cerello, P., Fiorina, E., Garbolino, S., Monaco, V., Vignati, A., Wheadon, R., Ferrero, V., & Rafecas, M. (2024). Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain. Paper presented at 2022 IEEE Nuclear Science Symposium and Medical Imaging Conference, Milan, Italy. https://doi.org/10.1109/NSS/MIC44845.2022.10399204

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title = "Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain",

abstract = "Prompt Gamma Timing is a technique proposed for range monitoring in proton therapy. The experimental measurements so far are limited to a single secondary proton detector. In this study we present an innovative technique to merge the information from many detectors in different positions into a unique estimation of the beam particle motion in the spatiotemporal domain. We test the proposed method by means of Monte Carlo simulations, with various beam ranges and a number of primaries interesting for proton therapy monitoring (107). The method is based on the Maximum Likelihood Expectation Maximization algorithm, and we show its applicability with both MeV-range gamma detectors as well as lower energy detectors such as PET detectors. The preliminary results shown indicate a range resolution of about 5 mm. The ultimate goal of this study is to provide a robust mathematical instrument to expand the significance of Prompt Gamma Timing measurements, to be useful for the prototypes presently under construction by the treatment monitoring community.",

author = "F. Pennazio and Werner, \{Julius Friedemann\} and Marco Aglietta and P. Cerello and E. Fiorina and S. Garbolino and V. Monaco and Anna Vignati and R. Wheadon and V. Ferrero and Magdalena Rafecas",

year = "2024",

month = jan,

day = "26",

doi = "10.1109/NSS/MIC44845.2022.10399204",

language = "English",

note = "2022 IEEE Nuclear Science Symposium and Medical Imaging Conference ; Conference date: 05-11-2022 Through 12-11-2022",

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Pennazio, F, Werner, JF, Aglietta, M, Cerello, P, Fiorina, E, Garbolino, S, Monaco, V, Vignati, A, Wheadon, R, Ferrero, V & Rafecas, M 2024, 'Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain', Paper presented at 2022 IEEE Nuclear Science Symposium and Medical Imaging Conference, Milan, Italy, 05.11.22 - 12.11.22. https://doi.org/10.1109/NSS/MIC44845.2022.10399204

TY - CONF

T1 - Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain

AU - Pennazio, F.

AU - Werner, Julius Friedemann

AU - Aglietta, Marco

AU - Cerello, P.

AU - Fiorina, E.

AU - Garbolino, S.

AU - Monaco, V.

AU - Vignati, Anna

AU - Wheadon, R.

AU - Ferrero, V.

AU - Rafecas, Magdalena

PY - 2024/1/26

Y1 - 2024/1/26

N2 - Prompt Gamma Timing is a technique proposed for range monitoring in proton therapy. The experimental measurements so far are limited to a single secondary proton detector. In this study we present an innovative technique to merge the information from many detectors in different positions into a unique estimation of the beam particle motion in the spatiotemporal domain. We test the proposed method by means of Monte Carlo simulations, with various beam ranges and a number of primaries interesting for proton therapy monitoring (107). The method is based on the Maximum Likelihood Expectation Maximization algorithm, and we show its applicability with both MeV-range gamma detectors as well as lower energy detectors such as PET detectors. The preliminary results shown indicate a range resolution of about 5 mm. The ultimate goal of this study is to provide a robust mathematical instrument to expand the significance of Prompt Gamma Timing measurements, to be useful for the prototypes presently under construction by the treatment monitoring community.

AB - Prompt Gamma Timing is a technique proposed for range monitoring in proton therapy. The experimental measurements so far are limited to a single secondary proton detector. In this study we present an innovative technique to merge the information from many detectors in different positions into a unique estimation of the beam particle motion in the spatiotemporal domain. We test the proposed method by means of Monte Carlo simulations, with various beam ranges and a number of primaries interesting for proton therapy monitoring (107). The method is based on the Maximum Likelihood Expectation Maximization algorithm, and we show its applicability with both MeV-range gamma detectors as well as lower energy detectors such as PET detectors. The preliminary results shown indicate a range resolution of about 5 mm. The ultimate goal of this study is to provide a robust mathematical instrument to expand the significance of Prompt Gamma Timing measurements, to be useful for the prototypes presently under construction by the treatment monitoring community.

UR - https://www.mendeley.com/catalogue/538f3121-586b-3e14-8444-d1b4fb2a289b/

U2 - 10.1109/NSS/MIC44845.2022.10399204

DO - 10.1109/NSS/MIC44845.2022.10399204

M3 - Conference Papers

T2 - 2022 IEEE Nuclear Science Symposium and Medical Imaging Conference

Y2 - 5 November 2022 through 12 November 2022

ER -

Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain

Abstract

Conference

UN SDGs

Research Areas and Centers

DFG Research Classification Scheme

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