Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain

F. Pennazio*, Julius Friedemann Werner, Marco Aglietta, P. Cerello, E. Fiorina, S. Garbolino, V. Monaco, Anna Vignati, R. Wheadon, V. Ferrero, Magdalena Rafecas

*Corresponding author for this work


Prompt Gamma Timing is a technique proposed for range monitoring in proton therapy. The experimental measurements so far are limited to a single secondary proton detector. In this study we present an innovative technique to merge the information from many detectors in different positions into a unique estimation of the beam particle motion in the spatiotemporal domain. We test the proposed method by means of Monte Carlo simulations, with various beam ranges and a number of primaries interesting for proton therapy monitoring (107). The method is based on the Maximum Likelihood Expectation Maximization algorithm, and we show its applicability with both MeV-range gamma detectors as well as lower energy detectors such as PET detectors. The preliminary results shown indicate a range resolution of about 5 mm. The ultimate goal of this study is to provide a robust mathematical instrument to expand the significance of Prompt Gamma Timing measurements, to be useful for the prototypes presently under construction by the treatment monitoring community.
Original languageEnglish
Publication statusPublished - 26.01.2024
Event2022 IEEE Nuclear Science Symposium and Medical Imaging Conference - Milan, Italy
Duration: 05.11.202212.11.2022


Conference2022 IEEE Nuclear Science Symposium and Medical Imaging Conference
Abbreviated titleNSS/MIC

Research Areas and Centers

  • Academic Focus: Biomedical Engineering

DFG Research Classification Scheme

  • 205-32 Medical Physics, Biomedical Engineering

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