Protein translocation: Common themes from bacteria to man

Berit Jungnickel; Tom A. Rapoport; Enno Hartmann

doi:10.1016/0014-5793(94)00367-X

Protein translocation: Common themes from bacteria to man

Berit Jungnickel, Tom A. Rapoport^*, Enno Hartmann

^*Corresponding author for this work

Institute of Biology

Max Delbrück Center for Molecular Medicine

Abstract

Protein transport across the endoplasmic reticulum membrane in eukaryotes and across the cytoplasmic membrane in bacteria have turned out to be highly related. The core component of the translocation apparatus is the Sec61/SecYp complex; at least two of its subunits are conserved in evolution. The Sec61/SecYp complex is involved in both co- and post-translational transport pathways. The two modes require probably distinct additional components.

Original language	English
Journal	FEBS Letters
Volume	346
Issue number	1
Number of pages	5
ISSN	0014-5793
DOIs	https://doi.org/10.1016/0014-5793(94)00367-X
Publication status	Published - 06.06.1994

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10.1016/0014-5793(94)00367-X

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abstract = "Protein transport across the endoplasmic reticulum membrane in eukaryotes and across the cytoplasmic membrane in bacteria have turned out to be highly related. The core component of the translocation apparatus is the Sec61/SecYp complex; at least two of its subunits are conserved in evolution. The Sec61/SecYp complex is involved in both co- and post-translational transport pathways. The two modes require probably distinct additional components.",

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AB - Protein transport across the endoplasmic reticulum membrane in eukaryotes and across the cytoplasmic membrane in bacteria have turned out to be highly related. The core component of the translocation apparatus is the Sec61/SecYp complex; at least two of its subunits are conserved in evolution. The Sec61/SecYp complex is involved in both co- and post-translational transport pathways. The two modes require probably distinct additional components.

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Protein translocation: Common themes from bacteria to man

Abstract

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