Protein translocation: Common themes from bacteria to man

Berit Jungnickel, Tom A. Rapoport*, Enno Hartmann

*Corresponding author for this work


Protein transport across the endoplasmic reticulum membrane in eukaryotes and across the cytoplasmic membrane in bacteria have turned out to be highly related. The core component of the translocation apparatus is the Sec61/SecYp complex; at least two of its subunits are conserved in evolution. The Sec61/SecYp complex is involved in both co- and post-translational transport pathways. The two modes require probably distinct additional components.

Original languageEnglish
JournalFEBS Letters
Issue number1
Number of pages5
Publication statusPublished - 06.06.1994


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