Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10−6 − 10−10 mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)