Prostaglandin E2 and atriopeptin III oppose the contractile effect of angiotensin II in rat kidney mesangial cell cultures

Joachim Fandrey; Wolfgang Jelkmann

doi:10.1016/0090-6980(88)90311-5

Prostaglandin E₂ and atriopeptin III oppose the contractile effect of angiotensin II in rat kidney mesangial cell cultures

Joachim Fandrey^*, Wolfgang Jelkmann

^*Corresponding author for this work

Institute of Physiology

14 Citations (Scopus)

Abstract

Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10⁻⁶ − 10⁻¹⁰ mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E₂ and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E₂ synthesis in mesangial cell cultures.

Original language	English
Journal	Prostaglandins
Volume	36
Issue number	2
Pages (from-to)	249-257
Number of pages	9
ISSN	0090-6980
DOIs	https://doi.org/10.1016/0090-6980(88)90311-5
Publication status	Published - 1988

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0090-6980(88)90311-5

Cite this

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abstract = "Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10−6 − 10−10 mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.",

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N2 - Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10−6 − 10−10 mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.

AB - Effects of vasoconstrictory and of dilatory hormones were studied on the contractile activity of cultured rat kidney mesangial cells. By phase contrast microscopy, a rapid contraction was seen of most cells treated with angiotensine II (10−6 − 10−10 mol/L), which was sometimes followed by autonomous relaxation after 10 to 20 min. Prostaglandin E2 and antriopeptin III prevented the contractile effect of angiotensin II in a dose-dependent manner. Angiotensin II, but not atriopeptine III, stimulated prostaglandin E2 synthesis in mesangial cell cultures.

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