TY - JOUR
T1 - Progression in disability and regional grey matter atrophy in relapsing-remitting multiple sclerosis
AU - Hofstetter, Louis
AU - Naegelin, Yvonne
AU - Filli, Lukas
AU - Kuster, Pascal
AU - Traud, Stefan
AU - Smieskova, Renata
AU - Mueller-Lenke, Nicole
AU - Kappos, Ludwig
AU - Gass, Achim
AU - Sprenger, Till
AU - Penner, Iris Katharina
AU - Nichols, Thomas E.
AU - Vrenken, Hugo
AU - Barkhof, Frederik
AU - Polman, Chris
AU - Radue, Ernst Wilhelm
AU - Borgwardt, Stefan J.
AU - Bendfeldt, Kerstin
PY - 2014/2
Y1 - 2014/2
N2 - Background: In multiple sclerosis (MS) regional grey matter (GM) atrophy has been associated with disability progression. Objective: The aim of this study was to compare regional GM volume changes in relapsing-remitting MS (RRMS) patients with progressive and stable disability, using voxel-based morphometry (VBM). Methods: We acquired baseline and 1-year follow-up 3-dimensional (3D) T1-weighted magnetic resonance imaging (MRI) data of RRMS patients, using two 1.5-Tesla scanners. Patients were matched pair-wise with respect to age, gender, disease duration, medication, scanner and baseline Expanded Disability Status Scale (EDSS) into 13 pairs, with either progressive EDSS (≥ 1 point change y-1) or stable EDSS, as well as into 29 pairs with either progressive Multiple Sclerosis Functional Composite (MSFC) at ≥ 0.25% decrease in y -1 in any component, or stable MSFC. We analysed longitudinal regional differences in GM volumes in the progressive and stable EDSS and MSFC groups, respectively, using VBM. Results: Significant GM volume reductions occurred in the right precuneus, in the progressive EDSS group. Differential between-group effects occurred in the right precuneus and in the postcentral gyrus. Further longitudinal GM volume reductions occurred in the right orbicular gyrus, in the progressive MSFC group, but no between-group differences were observed (non-stationary cluster-wise inference, all Pcorrected < 0.05). Conclusion: These results suggested a direct association of disability progression and regional GM atrophy in RRMS.
AB - Background: In multiple sclerosis (MS) regional grey matter (GM) atrophy has been associated with disability progression. Objective: The aim of this study was to compare regional GM volume changes in relapsing-remitting MS (RRMS) patients with progressive and stable disability, using voxel-based morphometry (VBM). Methods: We acquired baseline and 1-year follow-up 3-dimensional (3D) T1-weighted magnetic resonance imaging (MRI) data of RRMS patients, using two 1.5-Tesla scanners. Patients were matched pair-wise with respect to age, gender, disease duration, medication, scanner and baseline Expanded Disability Status Scale (EDSS) into 13 pairs, with either progressive EDSS (≥ 1 point change y-1) or stable EDSS, as well as into 29 pairs with either progressive Multiple Sclerosis Functional Composite (MSFC) at ≥ 0.25% decrease in y -1 in any component, or stable MSFC. We analysed longitudinal regional differences in GM volumes in the progressive and stable EDSS and MSFC groups, respectively, using VBM. Results: Significant GM volume reductions occurred in the right precuneus, in the progressive EDSS group. Differential between-group effects occurred in the right precuneus and in the postcentral gyrus. Further longitudinal GM volume reductions occurred in the right orbicular gyrus, in the progressive MSFC group, but no between-group differences were observed (non-stationary cluster-wise inference, all Pcorrected < 0.05). Conclusion: These results suggested a direct association of disability progression and regional GM atrophy in RRMS.
UR - http://www.scopus.com/inward/record.url?scp=84893561407&partnerID=8YFLogxK
U2 - 10.1177/1352458513493034
DO - 10.1177/1352458513493034
M3 - Journal articles
C2 - 23804554
AN - SCOPUS:84893561407
SN - 1352-4585
VL - 20
SP - 202
EP - 213
JO - Multiple Sclerosis
JF - Multiple Sclerosis
IS - 2
ER -
