TY - JOUR
T1 - Progress of Pharmacological Approaches in Parkinson's Disease
AU - Zeuner, Kirsten E.
AU - Schäffer, Eva
AU - Hopfner, Franziska
AU - Brüggemann, Norbert
AU - Berg, Daniela
N1 - © 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - The progressive neurodegenerative process in Parkinson's disease (PD) is not restricted to dopaminergic midbrain neurons but involves the entire nervous system. In this review, we outline established treatment options at different disease stages and address new therapeutic approaches. These include, based on recent advances in the understanding of the pathophysiology of PD, genetic and disease-modifying approaches to reduce abnormal accumulation and aggregation of alpha-synuclein (aSYN), mitochondrial dysfunction, and dysfunction of lysosomal proteins. Moreover, we highlight clinical trials to reduce neuroinflammation and increase neurorestoration.
AB - The progressive neurodegenerative process in Parkinson's disease (PD) is not restricted to dopaminergic midbrain neurons but involves the entire nervous system. In this review, we outline established treatment options at different disease stages and address new therapeutic approaches. These include, based on recent advances in the understanding of the pathophysiology of PD, genetic and disease-modifying approaches to reduce abnormal accumulation and aggregation of alpha-synuclein (aSYN), mitochondrial dysfunction, and dysfunction of lysosomal proteins. Moreover, we highlight clinical trials to reduce neuroinflammation and increase neurorestoration.
UR - http://www.scopus.com/inward/record.url?scp=85063321964&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/progress-pharmacological-approaches-parkinsons-disease
U2 - 10.1002/cpt.1374
DO - 10.1002/cpt.1374
M3 - Scientific review articles
C2 - 30661251
AN - SCOPUS:85063321964
SN - 0009-9236
VL - 105
SP - 1106
EP - 1120
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 5
ER -