Abstract
Normal airways below the carina maintain an essentially sterile environment via a multi-pronged innate defence system that includes mucus clearance via mucociliary clearance and cough, multiple antimicrobials and cellular components including macrophages and neutrophils. In cystic fibrosis (CF), loss of CFTR function compromises these defences, and with present standard of care virtually all people with CF eventually develop mucus accumulation, plugging and chronic infections. This review focuses on how mucus is affected by CFTR loss.
Original language | English |
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Journal | Journal of Cystic Fibrosis |
Volume | 17 |
Issue number | 2 |
Pages (from-to) | S35-S39 |
ISSN | 1569-1993 |
DOIs | |
Publication status | Published - 03.2018 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)