Progress in understanding mucus abnormalities in cystic fibrosis airways

Jeffrey J. Wine*, Gunnar C. Hansson, Peter König, Nam Soo Joo, Anna Ermund, Mario Pieper

*Corresponding author for this work
17 Citations (Scopus)


Normal airways below the carina maintain an essentially sterile environment via a multi-pronged innate defence system that includes mucus clearance via mucociliary clearance and cough, multiple antimicrobials and cellular components including macrophages and neutrophils. In cystic fibrosis (CF), loss of CFTR function compromises these defences, and with present standard of care virtually all people with CF eventually develop mucus accumulation, plugging and chronic infections. This review focuses on how mucus is affected by CFTR loss.

Original languageEnglish
JournalJournal of Cystic Fibrosis
Issue number2
Pages (from-to)S35-S39
Publication statusPublished - 03.2018

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


Dive into the research topics of 'Progress in understanding mucus abnormalities in cystic fibrosis airways'. Together they form a unique fingerprint.

Cite this