Prognostic value of microvascular obstruction and infarct size, as measured by CMR in STEMI patients

Matthijs Van Kranenburg; Michael Magro; Holger Thiele; Suzanne DeWaha; Ingo Eitel; Alexandre Cochet; Yves Cottin; Dan Atar; Peter Buser; Edwin Wu; Daniel Lee; Vicente Bodi; Gert Klug; Bernhard Metzler; Ronak Delewi; Peter Bernhardt; Wolfgang Rottbauer; Eric Boersma; Felix Zijlstra; Robert Jan Van Geuns

doi:10.1016/j.jcmg.2014.05.010

Prognostic value of microvascular obstruction and infarct size, as measured by CMR in STEMI patients

Matthijs Van Kranenburg, Michael Magro, Holger Thiele, Suzanne DeWaha, Ingo Eitel, Alexandre Cochet, Yves Cottin, Dan Atar, Peter Buser, Edwin Wu, Daniel Lee, Vicente Bodi, Gert Klug, Bernhard Metzler, Ronak Delewi, Peter Bernhardt, Wolfgang Rottbauer, Eric Boersma, Felix Zijlstra, Robert Jan Van Geuns^*

^*Corresponding author for this work

Department of Internal Medicine II

326 Citations (Scopus)

Abstract

The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (IS%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS% LV $25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE.

Original language	English
Journal	JACC: Cardiovascular Imaging
Volume	7
Issue number	9
Pages (from-to)	930-939
Number of pages	10
ISSN	1936-878X
DOIs	https://doi.org/10.1016/j.jcmg.2014.05.010
Publication status	Published - 2014

Funding

Dr. Bodi has received grant PI 1102323 from the Instituto de Salud Carlos III, Madrid, Spain, and PROMOTEO/2013/007 from the Conselleria de Educacio, Cultura I Esport (Generalitat Valenciana), Valencia, Spain. Dr. Delewi has received a grant from the Dutch Heart Foundation and National Health Insurance Board/ZON MW (grant no. 2011 T022 + 40-00703-98-11629). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Centers: Cardiological Center Luebeck (UHZL)

DFG Research Classification Scheme

2.22-12 Cardiology, Angiology

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10.1016/j.jcmg.2014.05.010

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Van Kranenburg, M., Magro, M., Thiele, H., DeWaha, S., Eitel, I., Cochet, A., Cottin, Y., Atar, D., Buser, P., Wu, E., Lee, D., Bodi, V., Klug, G., Metzler, B., Delewi, R., Bernhardt, P., Rottbauer, W., Boersma, E., Zijlstra, F., & Van Geuns, R. J. (2014). Prognostic value of microvascular obstruction and infarct size, as measured by CMR in STEMI patients. JACC: Cardiovascular Imaging, 7(9), 930-939. https://doi.org/10.1016/j.jcmg.2014.05.010

@article{436bb3dfc43d4bd4a4e625ea56e59d53,

title = "Prognostic value of microvascular obstruction and infarct size, as measured by CMR in STEMI patients",

abstract = "The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (IS\%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95\% confidence interval: 2.21 to 6.34). IS\% LV \$25\% was not associated with MACE (adjusted hazard ratio: 0.90; 95\% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS\%LV is not independently associated with MACE.",

author = "\{Van Kranenburg\}, Matthijs and Michael Magro and Holger Thiele and Suzanne DeWaha and Ingo Eitel and Alexandre Cochet and Yves Cottin and Dan Atar and Peter Buser and Edwin Wu and Daniel Lee and Vicente Bodi and Gert Klug and Bernhard Metzler and Ronak Delewi and Peter Bernhardt and Wolfgang Rottbauer and Eric Boersma and Felix Zijlstra and \{Van Geuns\}, \{Robert Jan\}",

note = "Publisher Copyright: {\textcopyright} 2014 by the American College of Cardiology Foundation.",

year = "2014",

doi = "10.1016/j.jcmg.2014.05.010",

language = "English",

volume = "7",

pages = "930--939",

journal = "JACC: Cardiovascular Imaging",

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Van Kranenburg, M, Magro, M, Thiele, H, DeWaha, S, Eitel, I, Cochet, A, Cottin, Y, Atar, D, Buser, P, Wu, E, Lee, D, Bodi, V, Klug, G, Metzler, B, Delewi, R, Bernhardt, P, Rottbauer, W, Boersma, E, Zijlstra, F & Van Geuns, RJ 2014, 'Prognostic value of microvascular obstruction and infarct size, as measured by CMR in STEMI patients', JACC: Cardiovascular Imaging, vol. 7, no. 9, pp. 930-939. https://doi.org/10.1016/j.jcmg.2014.05.010

TY - JOUR

T1 - Prognostic value of microvascular obstruction and infarct size, as measured by CMR in STEMI patients

AU - Van Kranenburg, Matthijs

AU - Magro, Michael

AU - Thiele, Holger

AU - DeWaha, Suzanne

AU - Eitel, Ingo

AU - Cochet, Alexandre

AU - Cottin, Yves

AU - Atar, Dan

AU - Buser, Peter

AU - Wu, Edwin

AU - Lee, Daniel

AU - Bodi, Vicente

AU - Klug, Gert

AU - Metzler, Bernhard

AU - Delewi, Ronak

AU - Bernhardt, Peter

AU - Rottbauer, Wolfgang

AU - Boersma, Eric

AU - Zijlstra, Felix

AU - Van Geuns, Robert Jan

PY - 2014

Y1 - 2014

N2 - The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (IS%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS% LV $25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE.

AB - The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (IS%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS% LV $25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE.

UR - https://www.scopus.com/pages/publications/84922606455

U2 - 10.1016/j.jcmg.2014.05.010

DO - 10.1016/j.jcmg.2014.05.010

M3 - Scientific review articles

C2 - 25212799

AN - SCOPUS:84922606455

SN - 1936-878X

VL - 7

SP - 930

EP - 939

JO - JACC: Cardiovascular Imaging

JF - JACC: Cardiovascular Imaging

IS - 9

ER -

Prognostic value of microvascular obstruction and infarct size, as measured by CMR in STEMI patients

Abstract

Funding

UN SDGs

Research Areas and Centers

DFG Research Classification Scheme

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