Abstract
Background:Prostate cancer (PCa) patients are often over-treated because of the lack of biomarkers needed to distinguish the lethal from the indolent form of PCa. YWHAZ was recently identified as a potential therapeutic target in castration-resistant PCa (CRPC). Therefore, this study focused on determining the prognostic significance of YWHAZ in localized PCa.Methods:YWHAZ expression was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tissue from 213 men who underwent radical prostatectomy. Kaplan-Meier analysis and Cox proportional-hazards models were used to assess the prognostic value of YWHAZ intensity.Results:High YWHAZ expression was strongly associated with high Gleason score at the time of diagnosis (P<0.001) and PSA relapse (P=0.001). Importantly, patients with high expression of YWHAZ had a higher risk of CRPC development (P=0.002) and reduced survival time (P=0.002).Conclusions:Our findings indicate that YWHAZ could serve as a promising prognostic biomarker in localized PCa to predict poor prognosis and to identify a subgroup of tumors, which might benefit from earlier adjuvant or YWHAZ-targeted therapy.
| Original language | English |
|---|---|
| Journal | Prostate Cancer and Prostatic Diseases |
| Volume | 17 |
| Issue number | 4 |
| Pages (from-to) | 310-314 |
| Number of pages | 5 |
| ISSN | 1365-7852 |
| DOIs | |
| Publication status | Published - 13.12.2014 |
Funding
This work was supported by grants from the Wilhelm Sander Foundation (2011.077.1), the Rudolf-Becker-Foundation and the German Research Foundation (Deutsche Forschungsgemeinschaft (DFG), Emmy-Noether-Program, PE1179/2-1) to SP. Furthermore, the project was supported by the medical student research grant of the Medical Faculty of the University of Bonn (BONFOR) to KR.
