TY - JOUR
T1 - Prognostic Factors of Survival after Radiotherapy for Lung Cancer–The Impact of Smoking Pack Years
AU - Werner, Elisa M.
AU - Glatzel, Esther
AU - Bohnet, Sabine
AU - Schild, Steven E.
AU - Rades, Dirk
N1 - Publisher Copyright:
© 2022 International Institute of Anticancer Research. All rights reserved.
PY - 2022/5
Y1 - 2022/5
N2 - Background/Aim: The prognostic role of smoking pack years after thoracic irradiation for lung cancer needs further clarification, since previous studies showed conflicting results. Therefore, this study investigated potential prognostic factors for survival including pack years in 170 lung cancer patients receiving local radiotherapy. Patients and Methods: Twelve factors were retrospectively evaluated for survival including age, sex, tumor site, histology, primary tumor stage, nodal stage, distant metastasis, radiation dose, upfront surgery or systemic treatment, pulmonary function, and number of pack years. Results: On univariate analyses, absence of distant metastasis (p=0.049), radiation dose >56 Gy (p=0.019), and ≤40 pack years (p=0.005) were significantly associated with better survival. In the multivariate analysis, number of pack years (hazard ratio 2.18, 95% confidence interval 1.25-3.82, p=0.006) maintained significance; distant metastasis (p=0.34) and radiation dose (p=0.16) were not significant. Conclusion: Number of pack years was an independent predictor of survival after thoracic irradiation for lung cancer.
AB - Background/Aim: The prognostic role of smoking pack years after thoracic irradiation for lung cancer needs further clarification, since previous studies showed conflicting results. Therefore, this study investigated potential prognostic factors for survival including pack years in 170 lung cancer patients receiving local radiotherapy. Patients and Methods: Twelve factors were retrospectively evaluated for survival including age, sex, tumor site, histology, primary tumor stage, nodal stage, distant metastasis, radiation dose, upfront surgery or systemic treatment, pulmonary function, and number of pack years. Results: On univariate analyses, absence of distant metastasis (p=0.049), radiation dose >56 Gy (p=0.019), and ≤40 pack years (p=0.005) were significantly associated with better survival. In the multivariate analysis, number of pack years (hazard ratio 2.18, 95% confidence interval 1.25-3.82, p=0.006) maintained significance; distant metastasis (p=0.34) and radiation dose (p=0.16) were not significant. Conclusion: Number of pack years was an independent predictor of survival after thoracic irradiation for lung cancer.
UR - http://www.scopus.com/inward/record.url?scp=85128900517&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/746f3ae4-1515-3dfa-8044-8060f530da5c/
U2 - 10.21873/invivo.12830
DO - 10.21873/invivo.12830
M3 - Journal articles
C2 - 35478154
AN - SCOPUS:85128900517
VL - 36
SP - 1297
EP - 1301
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 3
ER -
