Prognostic Factors for Complete Recovery From Xerostomia After Radiotherapy of Head-and-Neck Cancers

Dirk Rades*, Britta Warwas, Karsten Gerull, Ralph Pries, Anke Leichtle, Karl L. Bruchhage, Samer G. Hakim, Steven E. Schild, Florian Cremers

*Corresponding author for this work


Background/Aim: Radiotherapy of head-and-neck cancers can cause xerostomia. This study investigated potential prognostic factors for complete recovery from this complication. Patients and Methods: Eighty head-and-neck cancer patients with radiation-induced xerostomia were retrospectively evaluated. Thirteen characteristics were analyzed for complete recovery (to grade 0) from xerostomia including age, sex, tumor site and stage, nodal stage, upfront surgery, mean dose to ipsilateral, contralateral and both parotid glands, chemotherapy, radiation type and dose, and initial grade of xerostomia. Results: Fifteen patients (18.8%) experienced complete recovery of xerostomia. Significant associations with complete recovery were found for initial grade 1 xerostomia (p<0.001), mean dose to contralateral parotid gland of <20 Gy (p=0.034), and radiation treatment without chemotherapy (p=0.047). Conclusion: Almost every fifth patient experienced complete recovery of xerostomia. Prognostic factors were identified that can guide radiation oncologists during the process of treatment planning.

Original languageEnglish
JournalIn Vivo
Issue number4
Pages (from-to)1795-1800
Number of pages6
Publication statusPublished - 07.2022

Research Areas and Centers

  • Centers: University Cancer Center Schleswig-Holstein (UCCSH)
  • Research Area: Luebeck Integrated Oncology Network (LION)


Dive into the research topics of 'Prognostic Factors for Complete Recovery From Xerostomia After Radiotherapy of Head-and-Neck Cancers'. Together they form a unique fingerprint.

Cite this