Prognostic factors after whole-brain radiotherapy alone for brain metastases from malignant melanoma

Dirk Rades*, Lena Sehmisch, Stefan Janssen, Steven E. Schild

*Corresponding author for this work
2 Citations (Scopus)


Background/Aim: Many patients with brain metastases from melanoma receive whole-brain radiotherapy (WBRT). WBRT-regimens must consider the patient's prognosis in order to deliver the best therapy. Patients and Methods: Seven factors were correlated to intracerebral control and survival after WBRT alone in 92 patients with melanoma: WBRT regimen, age at WBRT, gender, Karnofsky performance score (KPS), number of brain lesions, number of extracranial metastatic sites, and time from melanoma diagnosis to WBRT. Results: On univariate analyses, KPS ≥80 (p=0.075) showed a trend towards improved intracerebral control. Greater WBRT dose (p=0.029), age ≤60 years (p=0.002), KPS ≥80 (p<0.001) and no extracranial site (p=0.008) were positively correlated with survival. On multivariate analyses, KPS (hazard ratio=2.11, 95% confidence interval=1.28-3.47; p=0.003) and number of extracranial metastatic sites (hazard ratio=1.27, 95% confidence interval=1.02-1.56; p=0.030) maintained significance regarding survival. Conclusion: The study identified predictors of survival for patients with melanoma receiving WBRT for brain metastases that can contribute to selection of individualized therapies.

Original languageEnglish
JournalAnticancer Research
Issue number12
Pages (from-to)6637-6640
Number of pages4
Publication statusPublished - 12.2016


Dive into the research topics of 'Prognostic factors after whole-brain radiotherapy alone for brain metastases from malignant melanoma'. Together they form a unique fingerprint.

Cite this