Prognostic factors after definitive radio(chemo)therapy of locally advanced head and neck cancer

Daniel Seidl, Stefan Janssen, Primoz Strojan, Amira Bajrovic, Steven E. Schild, Dirk Rades*

*Corresponding author for this work
5 Citations (Scopus)


Aim: To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN). Patients and Methods: Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m2 of cisplatin weekly, three courses of cisplatin 100 mg/m2, two courses of cisplatin 5×20 mg/m2 or two courses of cisplatin 5×20 mg/m2plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose. Results: On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS ≥80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m2 or 5×20 mg/m2 (p<0.001) were predictors of improved OS. Conclusion: Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted.

Original languageEnglish
JournalAnticancer Research
Issue number5
Pages (from-to)2523-2526
Number of pages4
Publication statusPublished - 2016


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