TY - JOUR
T1 - Prognostic factors after definitive radio(chemo)therapy of locally advanced head and neck cancer
AU - Seidl, Daniel
AU - Janssen, Stefan
AU - Strojan, Primoz
AU - Bajrovic, Amira
AU - Schild, Steven E.
AU - Rades, Dirk
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016
Y1 - 2016
N2 - Aim: To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN). Patients and Methods: Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m2 of cisplatin weekly, three courses of cisplatin 100 mg/m2, two courses of cisplatin 5×20 mg/m2 or two courses of cisplatin 5×20 mg/m2plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose. Results: On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS ≥80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m2 or 5×20 mg/m2 (p<0.001) were predictors of improved OS. Conclusion: Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted.
AB - Aim: To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN). Patients and Methods: Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m2 of cisplatin weekly, three courses of cisplatin 100 mg/m2, two courses of cisplatin 5×20 mg/m2 or two courses of cisplatin 5×20 mg/m2plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose. Results: On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS ≥80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m2 or 5×20 mg/m2 (p<0.001) were predictors of improved OS. Conclusion: Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted.
UR - http://www.scopus.com/inward/record.url?scp=85018710353&partnerID=8YFLogxK
M3 - Journal articles
C2 - 27127167
AN - SCOPUS:85018710353
SN - 0250-7005
VL - 36
SP - 2523
EP - 2526
JO - Anticancer Research
JF - Anticancer Research
IS - 5
ER -