Primary standard for liquid flow rates between 30 and 1500 nl/min based on volume expansion

Peter Lucas*, Martin Ahrens, Jan Geršl, Wouter Sparreboom, Joost Lötters

*Corresponding author for this work
7 Citations (Scopus)


An increasing number of microfluidic systems operate at flow rates below 1 μl/min. Applications include (implanted) micropumps for drug delivery, liquid chromatography, and microreactors. For the applications where the absolute accuracy is important, a proper calibration is required. However, with standard calibration facilities, flow rate calibrations below ~1 μl/min are not feasible because of a too large calibration uncertainty. In the current research, a traceable flow rate using a certain temperature increase rate is proposed. When the fluid properties, starting mass, and temperature increase rate are known, this principle yields a direct link to SI units, which makes it a primary standard. In this article, it will be shown that this principle enables flow rate uncertainties in the order of 2-3% for flow rates from 30 to 1500 nl/min.

Original languageEnglish
JournalBiomedizinische Technik
Issue number4
Pages (from-to)317-335
Number of pages19
Publication statusPublished - 01.08.2015

Research Areas and Centers

  • Academic Focus: Biomedical Engineering


Dive into the research topics of 'Primary standard for liquid flow rates between 30 and 1500 nl/min based on volume expansion'. Together they form a unique fingerprint.

Cite this