Primary mucinous adenocarcinoma of the renal pelvis with carcinoma in situ in the ureter

Mahmoud Abbas*, Mario W. Kramer, Tilmann Spieker, Thomas R.W. Herrman, Axel S. Merseburger, Klaus Michael Müller, Marcus A. Kuczyk, Jan U. Becker, Hans Heinrich Kreipe

*Corresponding author for this work
5 Citations (Scopus)


Primary epithelial tumor of the renal pelvis is rare and only 100 cases are reported in the literature [1]. Histological examination of the tumor showed glands, cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei. Scattered signet ring-type cells were also seen floating in large pools of extracellular mucin. Sections from the ureter showed a component of adenocarcinoma in situ. No invasive tumor was identified in ureteric tissue. One case was reported with carcinoma in situ of the ureter (2).Immunohistochemically: The tumor showed positivity for CK7, CK20, CK8/18, GATA-3, MSH-2, MSH-6, MLH-1, Ber-EP4, and S-100-P with focal positivity for CDX-2, weak positivity for PMS-2 and negativity in TTF-1 and Her-2. Molecular pathological analysis revealed microsatellite stability and without mutation in K-ras-gene. Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis with in situ adenocarcinoma of the ureter was made.

Original languageEnglish
JournalJournal of the Egyptian National Cancer Institute
Issue number1
Pages (from-to)51-54
Number of pages4
Publication statusPublished - 03.2014

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


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