Prevention of oxaliplatin-induced peripheral sensory neuropathy by carbamazepine in patients with advanced colorectal cancer

Christian Lersch*, Renate Schmelz, Florian Eckel, Johannes Erdmann, Martina Mayr, Ewert Schulte-Frohlinde, Stefan Quasthoff, Julian Grosskreutz, Helmuth Adelsberger

*Corresponding author for this work
68 Citations (Scopus)

Abstract

Oxaliplatin plays a key role in the treatment of advanced colorectal cancer. The dose-limiting side effect of this platinum analogue is neurotoxicity. Significant efforts have been undertaken in an attempt to prevent and/or circumvent the development of neurotoxicity. Sodium channel inactivation kinetics on rat sensory sural nerve preparations are altered after exposure to oxaliplatin. Carbamazepine antagonizes this effect in vitro. Results from preliminary clinical studies indicate that the sodium channel blockers carbamazepine and gabapentin may be effective in preventing neurotoxicity. The role of amifostine is not yet clear. Randomized clinical studies are necessary to confirm the potential benefit of carbamazepine and other sodium channel blockers in preventing and/or overcoming the development of oxaliplatin-induced neurotoxicity.

Original languageEnglish
Article number70504
JournalClinical Colorectal Cancer
Volume2
Issue number1
Pages (from-to)54-58
Number of pages5
ISSN1533-0028
DOIs
Publication statusPublished - 2002
Externally publishedYes

Research Areas and Centers

  • Centers: Center for Neuromuscular Diseases

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