TY - JOUR
T1 - Prevention of oxaliplatin-induced peripheral sensory neuropathy by carbamazepine in patients with advanced colorectal cancer
AU - Lersch, Christian
AU - Schmelz, Renate
AU - Eckel, Florian
AU - Erdmann, Johannes
AU - Mayr, Martina
AU - Schulte-Frohlinde, Ewert
AU - Quasthoff, Stefan
AU - Grosskreutz, Julian
AU - Adelsberger, Helmuth
PY - 2002
Y1 - 2002
N2 - Oxaliplatin plays a key role in the treatment of advanced colorectal cancer. The dose-limiting side effect of this platinum analogue is neurotoxicity. Significant efforts have been undertaken in an attempt to prevent and/or circumvent the development of neurotoxicity. Sodium channel inactivation kinetics on rat sensory sural nerve preparations are altered after exposure to oxaliplatin. Carbamazepine antagonizes this effect in vitro. Results from preliminary clinical studies indicate that the sodium channel blockers carbamazepine and gabapentin may be effective in preventing neurotoxicity. The role of amifostine is not yet clear. Randomized clinical studies are necessary to confirm the potential benefit of carbamazepine and other sodium channel blockers in preventing and/or overcoming the development of oxaliplatin-induced neurotoxicity.
AB - Oxaliplatin plays a key role in the treatment of advanced colorectal cancer. The dose-limiting side effect of this platinum analogue is neurotoxicity. Significant efforts have been undertaken in an attempt to prevent and/or circumvent the development of neurotoxicity. Sodium channel inactivation kinetics on rat sensory sural nerve preparations are altered after exposure to oxaliplatin. Carbamazepine antagonizes this effect in vitro. Results from preliminary clinical studies indicate that the sodium channel blockers carbamazepine and gabapentin may be effective in preventing neurotoxicity. The role of amifostine is not yet clear. Randomized clinical studies are necessary to confirm the potential benefit of carbamazepine and other sodium channel blockers in preventing and/or overcoming the development of oxaliplatin-induced neurotoxicity.
UR - http://www.scopus.com/inward/record.url?scp=0036018894&partnerID=8YFLogxK
U2 - 10.3816/CCC.2002.n.011
DO - 10.3816/CCC.2002.n.011
M3 - Journal articles
C2 - 12453338
AN - SCOPUS:0036018894
VL - 2
SP - 54
EP - 58
JO - Clinical Colorectal Cancer
JF - Clinical Colorectal Cancer
SN - 1533-0028
IS - 1
M1 - 70504
ER -