Prevalence of familial pancreatic cancer in Germany

Detlef K. Bartsch*, Ralf Kress, Mercedes Sina-Frey, Robert Grützmann, Berthold Gerdes, Christian Pilarsky, Joachim W. Heise, Klaus Martin Schulte, Mario Colombo-Benkmann, Cristina Schleicher, Helmut Witzigmann, Olaf Pridöhl, Michael B. Ghadimi, Olaf Horstmann, Wolfgang Von Bernstorff, Lisa Jochimsen, Jan Schmidt, Sven Eisold, Lope Estévéz-Schwarz, Stephan A. HahnKarsten Schulmann, Wolfgang Böck, Thomas M. Gress, Nikolaus Zügel, Karl Breitschaft, Klaus Prenzel, Helmut Messmann, Esther Endlicher, Margarete Schneider, Andreas Ziegler, Wolff Schmiegel, Helmut Schäfer, Matthias Rothmund, Harald Rieder

*Corresponding author for this work
66 Citations (Scopus)


Based on several case-control studies, it has been estimated that familial aggregation and genetic susceptibility play a role in up to 10% of patients with pancreatic cancer, although conclusive epidemiologic data are still lacking. Therefore, we evaluated the prevalence of familial pancreatic cancer and differences to its sporadic form in a prospective multicenter trial. A total of 479 consecutive patients with newly diagnosed, histologically confirmed adenocarcinoma of the pancreas were prospectively evaluated regarding medical and family history, treatment and pathology of the tumour. A family history for pancreatic cancer was confirmed whenever possible by reviewing the tumour specimens and medical reports. Statistical analysis was performed by calculating odds ratios, regression analysis with a logit-model and the Kaplan-Meier method. Twenty-three of 479 (prevalence 4.8%, 95% Cl 3.1-7.1) patients reported at least 1 first-degree relative with pancreatic cancer. The familial aggregation could be confirmed by histology in 5 of 23 patients (1.1%, 95% Cl 0.3-2.4), by medical records in 9 of 23 patients (1.9%, 95% Cl 0.9-3.5) and by standardized interviews of first-degree relatives in 17 of 23 patients (3.5%, 95% Cl 2.1-5.6), respectively. There were no statistical significant differences between familial and sporadic pancreatic cancer cases regarding sex ratio, age of onset, presence of diabetes mellitus and pancreatitis, tumour histology and stage, prognosis after pal liative or curative treatment as well as associated tumours in index patients and families, respectively. The prevalence of familial pancreatic cancer in Germany is at most 3.5% (range 1.1-3.5%) depending on the mode of confirmation of the pancreatic carcinoma in relatives. This prevalence is lower than so far postulated in the literature. There were no significant clinical differences between the familial and sporadic form of pancreatic cancer.

Original languageEnglish
JournalInternational Journal of Cancer
Issue number6
Pages (from-to)902-906
Number of pages5
Publication statusPublished - 20.07.2004


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