Abstract
Objective: To assess the prevalence of HDV infections in German blood donors. Method: 167 donors with acute/chronic or resolved HBV infection and detectable antibodies against Hepatitis B core antigen (anti-HBc) were tested for antibodies against HDV (anti-HDV) by competitive ELISA. Samples with detectable anti-HDV or with HBsAg and/or HBV DNA were additionally investigated for HDV RNA. Results: In nine (5.4 %) of the 167 donors, also HBsAg and HBV DNA were detectable. Anti-HDV was detectable in two of the 167 donors (1.2 %), additional four donors (2.4 %) had a borderline result. All of these donors tested negative for HBsAg and HBV DNA. Neither in samples with anti-HDV nor in HBsAg-/HBV DNA-positive samples, HDV RNA was detectable. Conclusions: At least 1.2 % of anti-HBc-positive blood donors have had an HDV infection. Although there is some evidence for a somewhat higher prevalence of HDV, the overall prevalence of HDV in Northern Germany is low.
| Original language | English |
|---|---|
| Article number | 102721 |
| Journal | Transfusion and Apheresis Science |
| Volume | 59 |
| Issue number | 3 |
| Pages (from-to) | 102721 |
| ISSN | 1473-0502 |
| DOIs | |
| Publication status | Published - 06.2020 |
Funding
The authors are indebted to Ursula Thiessen and the staff of the blood donor's laboratory in L?beck for the excellent technical assistance.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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