TY - JOUR
T1 - Prevalence of antibodies against Hepatitis D virus (HDV) in blood donors in Northern Germany
AU - Juhl, David
AU - Chudy, Michael
AU - Görg, Siegfried
AU - Hennig, Holger
N1 - Funding Information:
The authors are indebted to Ursula Thiessen and the staff of the blood donor's laboratory in L?beck for the excellent technical assistance.
Publisher Copyright:
© 2020 Elsevier Ltd
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Objective: To assess the prevalence of HDV infections in German blood donors. Method: 167 donors with acute/chronic or resolved HBV infection and detectable antibodies against Hepatitis B core antigen (anti-HBc) were tested for antibodies against HDV (anti-HDV) by competitive ELISA. Samples with detectable anti-HDV or with HBsAg and/or HBV DNA were additionally investigated for HDV RNA. Results: In nine (5.4 %) of the 167 donors, also HBsAg and HBV DNA were detectable. Anti-HDV was detectable in two of the 167 donors (1.2 %), additional four donors (2.4 %) had a borderline result. All of these donors tested negative for HBsAg and HBV DNA. Neither in samples with anti-HDV nor in HBsAg-/HBV DNA-positive samples, HDV RNA was detectable. Conclusions: At least 1.2 % of anti-HBc-positive blood donors have had an HDV infection. Although there is some evidence for a somewhat higher prevalence of HDV, the overall prevalence of HDV in Northern Germany is low.
AB - Objective: To assess the prevalence of HDV infections in German blood donors. Method: 167 donors with acute/chronic or resolved HBV infection and detectable antibodies against Hepatitis B core antigen (anti-HBc) were tested for antibodies against HDV (anti-HDV) by competitive ELISA. Samples with detectable anti-HDV or with HBsAg and/or HBV DNA were additionally investigated for HDV RNA. Results: In nine (5.4 %) of the 167 donors, also HBsAg and HBV DNA were detectable. Anti-HDV was detectable in two of the 167 donors (1.2 %), additional four donors (2.4 %) had a borderline result. All of these donors tested negative for HBsAg and HBV DNA. Neither in samples with anti-HDV nor in HBsAg-/HBV DNA-positive samples, HDV RNA was detectable. Conclusions: At least 1.2 % of anti-HBc-positive blood donors have had an HDV infection. Although there is some evidence for a somewhat higher prevalence of HDV, the overall prevalence of HDV in Northern Germany is low.
UR - http://www.scopus.com/inward/record.url?scp=85077994817&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/26bc0800-fe21-3a84-b3a3-73a0c5d722d5/
U2 - 10.1016/j.transci.2020.102721
DO - 10.1016/j.transci.2020.102721
M3 - Journal articles
C2 - 31964608
AN - SCOPUS:85077994817
SN - 1473-0502
VL - 59
SP - 102721
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
IS - 3
M1 - 102721
ER -
