Prevalence and Age Distribution of Pemphigus and Pemphigoid Diseases in Germany

Franziska Hübner, Andreas Recke, Detlef Zillikens, Roland Linder, Enno Schmidt*

*Corresponding author for this work
14 Citations (Scopus)


Autoimmune bullous diseases (AIBDs) are characterized by autoantibodies against structural proteins of the epidermis (pemphigus vulgaris and foliaceus) and dermal-epidermal junction (bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear IgA disease, and epidermolysis bullosa acquisita) (Schmidt and Groves, 2016). Clinically, blisters and erosions arise on skin and surface-close mucous membranes. Several reports have estimated the incidence of all AIBDs at between 13.3 and 66 cases per million people per year in Germany, the UK, Switzerland, France, Finland, Italy, and the US, with the highest incidences of bullous pemphigoid occurring in the population older than 80 years of age (150–300 cases/million people/year) and the lowest for epidermolysis bullous acquisita (0.2–0.5 cases/million people/year) (Bertram et al., 2009; Brick et al., 2014; Cozzani et al., 2001; Forsti et al., 2014; Joly et al., 2012; Langan et al., 2008; Marazza et al., 2009; reviewed in Schmidt et al., 2015).
Original languageEnglish
JournalJournal of Investigative Dermatology
Issue number12
Pages (from-to)2495-2498
Number of pages4
Publication statusPublished - 01.12.2016


Dive into the research topics of 'Prevalence and Age Distribution of Pemphigus and Pemphigoid Diseases in Germany'. Together they form a unique fingerprint.

Cite this