Preparation and characterization of dextran-covered Fe3O 4 nanoparticles for magnetic particle imaging

Kerstin Lüdtke-Buzug; Sven Biederer; Timo Sattel; Tobias Knopp; Thorsten M. Buzug

doi:10.1007/978-3-540-89208-3_562

Preparation and characterization of dextran-covered Fe₃O ₄ nanoparticles for magnetic particle imaging

Kerstin Lüdtke-Buzug^*, Sven Biederer, Timo Sattel, Tobias Knopp, Thorsten M. Buzug

^*Corresponding author for this work

Institute of Medical Engineering

Abstract

Magnetic particle imaging (MPI) is a recently proposed method for the visualization of the spatial distribution of iron-oxide nanoparticles. The principle is based on the superparamagnetic nature of Fe₃O ₄ particles (SPIOs). Iron-oxide particles covered with dextran and derivates are widely used as contrast agents in MRI imaging. However, besides the spatial bio-distribution the image quality of the magnetic-particle imaging concept is determined by the particle diameter as well. Moreover, it is the particle size distribution that affects the measured magnetization response within MPI. Therefore, the spectral analysis of the synthesized nanoparticles is an essential assay step for particle validation.

Original language	English
Title of host publication	4th European Conference of the International Federation for Medical and Biological Engineering
Editors	Jos Vander Sloten, Pascal Verdonck, Marc Nyssen, Jens Haueisen
Number of pages	4
Volume	22
Publisher	Springer Berlin Heidelberg
Publication date	2008
Pages	2343-2346
ISBN (Print)	978-3-540-89207-6
ISBN (Electronic)	978-3-540-89208-3
DOIs	https://doi.org/10.1007/978-3-540-89208-3_562
Publication status	Published - 2008
Event	4th European Conference of the International Federation for Medical and Biological Engineering - Antwerp, Belgium Duration: 23.11.2008 → 27.11.2008 Conference number: 81647

Research Areas and Centers

Academic Focus: Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-540-89208-3_562

Cite this

Lüdtke-Buzug, K., Biederer, S., Sattel, T., Knopp, T., & Buzug, T. M. (2008). Preparation and characterization of dextran-covered Fe₃O ₄ nanoparticles for magnetic particle imaging. In J. Vander Sloten, P. Verdonck, M. Nyssen, & J. Haueisen (Eds.), 4th European Conference of the International Federation for Medical and Biological Engineering (Vol. 22, pp. 2343-2346). (IFMBE Proceedings; Vol. 22). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-89208-3_562

Lüdtke-Buzug, Kerstin ; Biederer, Sven ; Sattel, Timo et al. / Preparation and characterization of dextran-covered Fe₃O ₄ nanoparticles for magnetic particle imaging. 4th European Conference of the International Federation for Medical and Biological Engineering. editor / Jos Vander Sloten ; Pascal Verdonck ; Marc Nyssen ; Jens Haueisen. Vol. 22 Springer Berlin Heidelberg, 2008. pp. 2343-2346 (IFMBE Proceedings).

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title = "Preparation and characterization of dextran-covered Fe3O 4 nanoparticles for magnetic particle imaging",

abstract = "Magnetic particle imaging (MPI) is a recently proposed method for the visualization of the spatial distribution of iron-oxide nanoparticles. The principle is based on the superparamagnetic nature of Fe3O 4 particles (SPIOs). Iron-oxide particles covered with dextran and derivates are widely used as contrast agents in MRI imaging. However, besides the spatial bio-distribution the image quality of the magnetic-particle imaging concept is determined by the particle diameter as well. Moreover, it is the particle size distribution that affects the measured magnetization response within MPI. Therefore, the spectral analysis of the synthesized nanoparticles is an essential assay step for particle validation.",

author = "Kerstin L{\"u}dtke-Buzug and Sven Biederer and Timo Sattel and Tobias Knopp and Buzug, {Thorsten M.}",

note = "Copyright: Copyright 2010 Elsevier B.V., All rights reserved.; 4th European Conference of the International Federation for Medical and Biological Engineering, ECIFMBE 2008 ; Conference date: 23-11-2008 Through 27-11-2008",

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doi = "10.1007/978-3-540-89208-3_562",

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Lüdtke-Buzug, K, Biederer, S, Sattel, T, Knopp, T & Buzug, TM 2008, Preparation and characterization of dextran-covered Fe₃O ₄ nanoparticles for magnetic particle imaging. in J Vander Sloten, P Verdonck, M Nyssen & J Haueisen (eds), 4th European Conference of the International Federation for Medical and Biological Engineering. vol. 22, IFMBE Proceedings, vol. 22, Springer Berlin Heidelberg, pp. 2343-2346, 4th European Conference of the International Federation for Medical and Biological Engineering, Antwerp, Belgium, 23.11.08. https://doi.org/10.1007/978-3-540-89208-3_562

Preparation and characterization of dextran-covered Fe₃O ₄ nanoparticles for magnetic particle imaging. / Lüdtke-Buzug, Kerstin; Biederer, Sven; Sattel, Timo et al.
4th European Conference of the International Federation for Medical and Biological Engineering. ed. / Jos Vander Sloten; Pascal Verdonck; Marc Nyssen; Jens Haueisen. Vol. 22 Springer Berlin Heidelberg, 2008. p. 2343-2346 (IFMBE Proceedings; Vol. 22).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

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AB - Magnetic particle imaging (MPI) is a recently proposed method for the visualization of the spatial distribution of iron-oxide nanoparticles. The principle is based on the superparamagnetic nature of Fe3O 4 particles (SPIOs). Iron-oxide particles covered with dextran and derivates are widely used as contrast agents in MRI imaging. However, besides the spatial bio-distribution the image quality of the magnetic-particle imaging concept is determined by the particle diameter as well. Moreover, it is the particle size distribution that affects the measured magnetization response within MPI. Therefore, the spectral analysis of the synthesized nanoparticles is an essential assay step for particle validation.

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Lüdtke-Buzug K, Biederer S, Sattel T, Knopp T, Buzug TM. Preparation and characterization of dextran-covered Fe₃O ₄ nanoparticles for magnetic particle imaging. In Vander Sloten J, Verdonck P, Nyssen M, Haueisen J, editors, 4th European Conference of the International Federation for Medical and Biological Engineering. Vol. 22. Springer Berlin Heidelberg. 2008. p. 2343-2346. (IFMBE Proceedings). doi: 10.1007/978-3-540-89208-3_562