Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease

K Reetz; H R Siebner; C Gaser; J Hagenah; C Buechel; M Kasten; D Petersen; P P Pramstaller; C Klein; F Binkofksi

doi:10.2174/1874440000802010102

Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease

K Reetz, H R Siebner, C Gaser, J Hagenah, C Buechel, M Kasten, D Petersen, P P Pramstaller, C Klein, F Binkofksi

Abstract

In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson's disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.

Original language	English
Journal	The open neuroimaging journal
Volume	2
Pages (from-to)	102-5
Number of pages	4
ISSN	1874-4400
DOIs	https://doi.org/10.2174/1874440000802010102
Publication status	Published - 27.09.2008

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title = "Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease",

abstract = "In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson's disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.",

author = "K Reetz and Siebner, \{H R\} and C Gaser and J Hagenah and C Buechel and M Kasten and D Petersen and Pramstaller, \{P P\} and C Klein and F Binkofksi",

year = "2008",

month = sep,

day = "27",

doi = "10.2174/1874440000802010102",

language = "English",

volume = "2",

pages = "102--5",

journal = "The open neuroimaging journal",

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TY - JOUR

T1 - Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease

AU - Reetz, K

AU - Siebner, H R

AU - Gaser, C

AU - Hagenah, J

AU - Buechel, C

AU - Kasten, M

AU - Petersen, D

AU - Pramstaller, P P

AU - Klein, C

AU - Binkofksi, F

PY - 2008/9/27

Y1 - 2008/9/27

N2 - In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson's disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.

AB - In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson's disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.

U2 - 10.2174/1874440000802010102

DO - 10.2174/1874440000802010102

M3 - Journal articles

C2 - 19526072

SN - 1874-4400

VL - 2

SP - 102

EP - 105

JO - The open neuroimaging journal

JF - The open neuroimaging journal

ER -

Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease

Abstract

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