Projects per year
Abstract
Background: To develop preliminary classification criteria for the cryoglobulinaemic syndrome or cryoglobulinaemic vasculitis (CV). Methods: Study part I developed a questionnaire for CV to be included in the formal, second part (study part II). Positivity of serum cryoglobulins was defined by experts as an essential condition for CV classification. In study part II, a core set of classification items (questionnaire, clinical and laboratory items, as agreed) was tested in three groups of patients and controls - that is, group A (new patients with the CV), group B (controls with serum cryoglobulins but lacking CV) and group C (controls without serum cryoglobulins but with features which can be observed in CV). Results: In study part I (188 cases, 284 controls), a positive response to at least two of three selected questions showed a sensitivity of 81.9% and a specificity of 83.5% for CV. This questionnaire was employed and validated in study part II, which included 272 patients in group A and 228 controls in group B. The final classification criteria for CV, by pooling data from group A and group B, required the positivity of questionnaire plus clinical, questionnaire plus laboratory, or clinical plus laboratory items, or all the three, providing a sensitivity of 88.5% and a specificity of 93.6% for CV. By comparing data in group A versus group C (425 controls), the same classification criteria showed a sensitivity 88.5% and a specificity 97.0% for CV. Conclusion: Classification criteria for CV were developed, and now need validation.
Original language | English |
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Journal | Annals of the Rheumatic Diseases |
Volume | 70 |
Issue number | 7 |
Pages (from-to) | 1183-1190 |
Number of pages | 8 |
ISSN | 0003-4967 |
DOIs | |
Publication status | Published - 01.07.2011 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
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Dive into the research topics of 'Preliminary classification criteria for the cryoglobulinaemic vasculitis'. Together they form a unique fingerprint.Projects
- 1 Finished
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CRU 170: Early Pathogenesis of Wegener's Granulomatosis: From Innate Immunity with Granuloma Formation to Autoimmunity.
Gross, W. & Lamprecht, P.
01.01.07 → 31.12.15
Project: DFG Projects › DFG Joint Research: Research Units/ Clinical Research Units