TY - JOUR
T1 - Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults
AU - Ganos, Christos
AU - Kühn, Simone
AU - Kahl, Ursula
AU - Schunke, Odette
AU - Brandt, Valerie
AU - Bäumer, Tobias
AU - Thomalla, Götz
AU - Haggard, Patrick
AU - Münchau, Alexander
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background: Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated. Methods: Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control. Results: Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition. Conclusion: Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology.
AB - Background: Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated. Methods: Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control. Results: Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition. Conclusion: Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology.
UR - http://www.scopus.com/inward/record.url?scp=84890582332&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychores.2013.10.014
DO - 10.1016/j.jpsychores.2013.10.014
M3 - Journal articles
C2 - 24360147
AN - SCOPUS:84890582332
SN - 0022-3999
VL - 76
SP - 84
EP - 87
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
IS - 1
ER -
