Predicting type 2 diabetes using an electronic nose-based artificial neural network analysis

E. I. Mohamed, R. Linder, G. Perriello, N. Di Daniele, S. J. Pöppl, A. De Lorenzo*

*Corresponding author for this work
60 Citations (Scopus)

Abstract

Diabetes is a major health problem in both industrial and developing countries, and its incidence is rising. Although detection of diabetes is improving, about half of the patients with Type 2 diabetes are undiagnosed and the delay from disease onset to diagnosis may exceed 10 yr. Thus, earlier detection of Type 2 diabetes and treatment of hyperglycaemia and related metabolic abnormalities is of vital importance. The objectives of the present study were to examine urine samples from Type 2 diabetic patients and healthy volunteers using the electronic nose technology and to evaluate possible application of data classification methods such as self-learning artificial neural networks (ANN) and logistic regression (LR) in comparison with principal components analysis (PCA). Urine samples from Type 2 diabetic patients and healthy controls were processed randomly using a simple 8-sensors electronic nose and individual electronic nose patterns were qualitatively classified using the "Approximation and Classification of Medical Data" (ACMD) network based on 2 output neurons, binary LR analysis and PCA. Distinct classes were found for Type 2 diabetic subjects and controls using PCA, which had a 96.0% successful classification percentage mean-while qualitative ANN analysis and LR analysis had successful classification percentages of 92.0% and 88.0%, respectively. Therefore, the ACMD network is suitable for classifying medical and clinical data.

Original languageEnglish
JournalDiabetes, Nutrition and Metabolism - Clinical and Experimental
Volume15
Issue number4
Pages (from-to)215-221
Number of pages7
ISSN0394-3402
Publication statusPublished - 01.08.2002

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