Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer

Liesa Dziggel; Markus Dahlke; Stefan Janssen; Dagmar Hornung; Oliver Blanck; Mai T.rong Khoa; Steven E. Schild; Dirk Rades

Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer

Liesa Dziggel, Markus Dahlke, Stefan Janssen, Dagmar Hornung, Oliver Blanck, Mai T.rong Khoa, Steven E. Schild, Dirk Rades

Clinic of Radiotherapy

9 Citations (Scopus)

Abstract

AIM: To generate a tool that estimates the probability of developing new cerebral metastases after stereotactic radiosurgery (SRS) in breast cancer patients.

PATIENTS AND METHODS: SRS dose plus seven characteristics (age, performance score, number of cerebral metastases, maximum diameter of all metastases, location of metastases, extra-cerebral spread and time from breast cancer diagnosis until SRS) were analyzed regarding their ability to predict the probability of new cerebral metastases development following SRS. For those characteristics deemed significant, points of 0 (higher risk of new lesions) or 1 (lower risk) were given. Scores were generated by adding the points of significant characteristics.

RESULTS: Performance score (p=0.013) and maximum diameter of all metastases (p=0.022) were associated with development of subsequent brain metastases. Two groups were created, 0-1 and 2 points. Freedom from new cerebral metastases rates were 27% and 92%, respectively, at 15 months (p=0.003).

CONCLUSION: This tool helps select breast cancer with few cerebral metastases receiving SRS who may benefit from additional whole-brain irradiation.

Original language	English
Journal	Anticancer Research
Volume	35
Issue number	12
Pages (from-to)	6793-6797
Number of pages	5
ISSN	0250-7005
Publication status	Published - 01.12.2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{5b06415185944bdcb754b97e28d06674,

title = "Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer",

abstract = "AIM: To generate a tool that estimates the probability of developing new cerebral metastases after stereotactic radiosurgery (SRS) in breast cancer patients.PATIENTS AND METHODS: SRS dose plus seven characteristics (age, performance score, number of cerebral metastases, maximum diameter of all metastases, location of metastases, extra-cerebral spread and time from breast cancer diagnosis until SRS) were analyzed regarding their ability to predict the probability of new cerebral metastases development following SRS. For those characteristics deemed significant, points of 0 (higher risk of new lesions) or 1 (lower risk) were given. Scores were generated by adding the points of significant characteristics.RESULTS: Performance score (p=0.013) and maximum diameter of all metastases (p=0.022) were associated with development of subsequent brain metastases. Two groups were created, 0-1 and 2 points. Freedom from new cerebral metastases rates were 27% and 92%, respectively, at 15 months (p=0.003).CONCLUSION: This tool helps select breast cancer with few cerebral metastases receiving SRS who may benefit from additional whole-brain irradiation.",

author = "Liesa Dziggel and Markus Dahlke and Stefan Janssen and Dagmar Hornung and Oliver Blanck and Khoa, {Mai T.rong} and Schild, {Steven E.} and Dirk Rades",

note = "Publisher Copyright: Copyright{\textcopyright} 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. Copyright: This record is sourced from MEDLINE{\textregistered}/PubMed{\textregistered}, a database of the U.S. National Library of Medicine",

year = "2015",

month = dec,

day = "1",

language = "English",

volume = "35",

pages = "6793--6797",

journal = "Anticancer Research",

issn = "0250-7005",

number = "12",

}

TY - JOUR

T1 - Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer

AU - Dziggel, Liesa

AU - Dahlke, Markus

AU - Janssen, Stefan

AU - Hornung, Dagmar

AU - Blanck, Oliver

AU - Khoa, Mai T.rong

AU - Schild, Steven E.

AU - Rades, Dirk

N1 - Publisher Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2015/12/1

Y1 - 2015/12/1

N2 - AIM: To generate a tool that estimates the probability of developing new cerebral metastases after stereotactic radiosurgery (SRS) in breast cancer patients.PATIENTS AND METHODS: SRS dose plus seven characteristics (age, performance score, number of cerebral metastases, maximum diameter of all metastases, location of metastases, extra-cerebral spread and time from breast cancer diagnosis until SRS) were analyzed regarding their ability to predict the probability of new cerebral metastases development following SRS. For those characteristics deemed significant, points of 0 (higher risk of new lesions) or 1 (lower risk) were given. Scores were generated by adding the points of significant characteristics.RESULTS: Performance score (p=0.013) and maximum diameter of all metastases (p=0.022) were associated with development of subsequent brain metastases. Two groups were created, 0-1 and 2 points. Freedom from new cerebral metastases rates were 27% and 92%, respectively, at 15 months (p=0.003).CONCLUSION: This tool helps select breast cancer with few cerebral metastases receiving SRS who may benefit from additional whole-brain irradiation.

AB - AIM: To generate a tool that estimates the probability of developing new cerebral metastases after stereotactic radiosurgery (SRS) in breast cancer patients.PATIENTS AND METHODS: SRS dose plus seven characteristics (age, performance score, number of cerebral metastases, maximum diameter of all metastases, location of metastases, extra-cerebral spread and time from breast cancer diagnosis until SRS) were analyzed regarding their ability to predict the probability of new cerebral metastases development following SRS. For those characteristics deemed significant, points of 0 (higher risk of new lesions) or 1 (lower risk) were given. Scores were generated by adding the points of significant characteristics.RESULTS: Performance score (p=0.013) and maximum diameter of all metastases (p=0.022) were associated with development of subsequent brain metastases. Two groups were created, 0-1 and 2 points. Freedom from new cerebral metastases rates were 27% and 92%, respectively, at 15 months (p=0.003).CONCLUSION: This tool helps select breast cancer with few cerebral metastases receiving SRS who may benefit from additional whole-brain irradiation.

UR - http://www.scopus.com/inward/record.url?scp=84973409090&partnerID=8YFLogxK

M3 - Journal articles

C2 - 26637898

AN - SCOPUS:84973409090

SN - 0250-7005

VL - 35

SP - 6793

EP - 6797

JO - Anticancer Research

JF - Anticancer Research

IS - 12

ER -

Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer

Abstract

UN SDGs

Other files and links

Fingerprint

Cite this