TY - JOUR
T1 - Predicting overall survival in patients with brain metastases from esophageal cancer
AU - Rades, Dirk
AU - Dziggel, Liesa
AU - Bartscht, Tobias
AU - Gliemroth, Jan
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Aim: To identify survival predictors and develop a survival score for patients with brain metastases from esophageal cancer. Patients and Methods: In 16 patients, seven factors were analyzed including age, gender, Karnofsky performance score (KPS), time from diagnosis of esophageal cancer to irradiation, number of brain metastases, histology, and presence of extracerebral metastases. Results: Improved survival was significantly associated with KPS ≥80 (p<0.001), the presence of one brain metastasis (p=0.007), and no extra-cerebral metastases (p=0.002). These factors were included in the final score. Factor scores were calculated by dividing 6-month survival rates by 10. Total survival scores represented the sums of factor scores and were 2, 7, 10, 19 or 24 points. Six-month survival rates by score were 0%, 0%, 0%, 67% and 100%, respectively. Two groups were formed, those of patients with 2-10 points and those with 19-24 points; 6-month survival was 0% and 88%, respectively (p<0.001). Conclusion: This new score facilitates the selection of individual therapies for patients with brain metastases from esophageal cancer.
AB - Aim: To identify survival predictors and develop a survival score for patients with brain metastases from esophageal cancer. Patients and Methods: In 16 patients, seven factors were analyzed including age, gender, Karnofsky performance score (KPS), time from diagnosis of esophageal cancer to irradiation, number of brain metastases, histology, and presence of extracerebral metastases. Results: Improved survival was significantly associated with KPS ≥80 (p<0.001), the presence of one brain metastasis (p=0.007), and no extra-cerebral metastases (p=0.002). These factors were included in the final score. Factor scores were calculated by dividing 6-month survival rates by 10. Total survival scores represented the sums of factor scores and were 2, 7, 10, 19 or 24 points. Six-month survival rates by score were 0%, 0%, 0%, 67% and 100%, respectively. Two groups were formed, those of patients with 2-10 points and those with 19-24 points; 6-month survival was 0% and 88%, respectively (p<0.001). Conclusion: This new score facilitates the selection of individual therapies for patients with brain metastases from esophageal cancer.
UR - http://www.scopus.com/inward/record.url?scp=84916225464&partnerID=8YFLogxK
M3 - Journal articles
C2 - 25368288
AN - SCOPUS:84916225464
SN - 0250-7005
VL - 34
SP - 6763
EP - 6765
JO - Anticancer Research
JF - Anticancer Research
IS - 11
ER -
