Pre-and post-conditioning of the heart: An overview of cardioprotec-tive signaling pathways

Denise Coutinho de Miranda; Gabriela de Oliveira Faria; Milla Marques Hermidorff; Fernanda Cacilda Dos Santos Silva; Leonardo Vinícius Monteiro de Assis; Mauro César Isoldi

doi:10.2174/1570161119666201120160619

Pre-and post-conditioning of the heart: An overview of cardioprotec-tive signaling pathways

Denise Coutinho de Miranda, Gabriela de Oliveira Faria, Milla Marques Hermidorff, Fernanda Cacilda Dos Santos Silva, Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi^*

^*Corresponding author for this work

Institute of Neurobiology

Federal University of Ouro Preto

31 Citations (Scopus)

Abstract

Since the discovery of ischemic pre-and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre-and post-conditioning is promising.

Original language	English
Journal	Current Vascular Pharmacology
Volume	19
Issue number	5
Pages (from-to)	499-524
Number of pages	26
ISSN	1570-1611
DOIs	https://doi.org/10.2174/1570161119666201120160619
Publication status	Published - 2021

Funding

We thank the funding agencies PROP-UFOP, FAPEMIG, CAPES, and CNPq for financial support. We also thank the Research Center of Biological Science (NU-PEB-UFOP). de Assis, L.V.M is a fellow of FAPESP (2018/16511-8).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 8 Decent Work and Economic Growth
SDG 10 Reduced Inequalities

Access to Document

10.2174/1570161119666201120160619

Cite this

@article{54afaa26b4a749c8b362bd1ec31a9370,

title = "Pre-and post-conditioning of the heart: An overview of cardioprotec-tive signaling pathways",

abstract = "Since the discovery of ischemic pre-and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre-and post-conditioning is promising.",

author = "\{de Miranda\}, \{Denise Coutinho\} and Faria, \{Gabriela de Oliveira\} and Hermidorff, \{Milla Marques\} and Silva, \{Fernanda Cacilda Dos Santos\} and \{de Assis\}, \{Leonardo Vin{\'i}cius Monteiro\} and Isoldi, \{Mauro C{\'e}sar\}",

note = "Funding Information: We thank the funding agencies PROP-UFOP, FAPEMIG, CAPES, and CNPq for financial support. We also thank the Research Center of Biological Science (NU-PEB-UFOP). de Assis, L.V.M is a fellow of FAPESP (2018/16511-8). Publisher Copyright: {\textcopyright} 2021 Bentham Science Publishers.",

year = "2021",

doi = "10.2174/1570161119666201120160619",

language = "English",

volume = "19",

pages = "499--524",

journal = "Current Vascular Pharmacology",

issn = "1570-1611",

publisher = "Bentham Science Publishers",

number = "5",

}

TY - JOUR

T1 - Pre-and post-conditioning of the heart

T2 - An overview of cardioprotec-tive signaling pathways

AU - de Miranda, Denise Coutinho

AU - Faria, Gabriela de Oliveira

AU - Hermidorff, Milla Marques

AU - Silva, Fernanda Cacilda Dos Santos

AU - de Assis, Leonardo Vinícius Monteiro

AU - Isoldi, Mauro César

N1 - Funding Information: We thank the funding agencies PROP-UFOP, FAPEMIG, CAPES, and CNPq for financial support. We also thank the Research Center of Biological Science (NU-PEB-UFOP). de Assis, L.V.M is a fellow of FAPESP (2018/16511-8). Publisher Copyright: © 2021 Bentham Science Publishers.

PY - 2021

Y1 - 2021

N2 - Since the discovery of ischemic pre-and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre-and post-conditioning is promising.

AB - Since the discovery of ischemic pre-and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre-and post-conditioning is promising.

UR - https://www.scopus.com/pages/publications/85116172933

U2 - 10.2174/1570161119666201120160619

DO - 10.2174/1570161119666201120160619

M3 - Scientific review articles

C2 - 33222675

AN - SCOPUS:85116172933

SN - 1570-1611

VL - 19

SP - 499

EP - 524

JO - Current Vascular Pharmacology

JF - Current Vascular Pharmacology

IS - 5

ER -

Pre-and post-conditioning of the heart: An overview of cardioprotec-tive signaling pathways

Abstract

Funding

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this