Pre-and post-conditioning of the heart: An overview of cardioprotec-tive signaling pathways

Denise Coutinho de Miranda, Gabriela de Oliveira Faria, Milla Marques Hermidorff, Fernanda Cacilda Dos Santos Silva, Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi*

*Corresponding author for this work


Since the discovery of ischemic pre-and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre-and post-conditioning is promising.

Original languageEnglish
JournalCurrent Vascular Pharmacology
Issue number5
Pages (from-to)499-524
Number of pages26
Publication statusPublished - 2021


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