Prävalenz des Hepatitis-C-Virus bei Blutspendern und Vergleich von vier verschiedenen Anti-HCV-Differenzierungstests.

Translated title of the contribution: Prevalence of hepatitis C virus in blood donors and comparison of 4 different anti-HCV differentiation tests

H. Hennig*, D. Haase, H. Kirchner

*Corresponding author for this work
    2 Citations (Scopus)

    Abstract

    In 1994 we tested 30,208 blood donations in Lübeck with the Abbott HCV EIA 2.0. 88 specimens of 47 blood donors who were repeatedly reactive were the basis of comparative investigations with the Chiron RIBA HCV 2.0 and 3.0, the Abbott Matrix HCV, the Wellcozyme HCV Western Blot (Murex) and the PCR (Amplicor HCV Test, Roche Diagnostic Systems). Our results suggest that the minimal prevalence of HCV RNA amounts to approximately 0.13%, the incidence per year to 0.013%. The minimal prevalence of anti-HCV amounts to 0.27%. Anti-core antibodies are the most frequent anti-HCV antibodies. They may be the only detectable antibodies during the early phase of the infection. The Chiron RIBA HCV 3.0 with the synthetic peptide c22p is not sufficiently sensitive for anti-core antibodies and may therefore fail to recognize viremic specimens.

    Translated title of the contributionPrevalence of hepatitis C virus in blood donors and comparison of 4 different anti-HCV differentiation tests
    Original languageGerman
    JournalBeiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine
    Volume33
    Pages (from-to)231-234
    Number of pages4
    ISSN1023-2028
    Publication statusPublished - 1996

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