Potential role of polyunsaturated fatty acids, with particular regard to the signaling pathways of arachidonic acid and its derivatives in the process of maturation of the oocytes: Contemporary review

Masoumeh Khajeh, Reza Rahbarghazi*, Mohammad Nouri, Masoud Darabi

*Corresponding author for this work
24 Citations (Scopus)


Oocyte meiotic maturation is one of the significant physiological requirements for ovulation and fertility. It is believed that Cyclic Adenosine Monophosphate, protein kinase A and protein kinase C pathways along with eicosanoids, particularly prostaglandin E2, and steroids are the key factors regulating mammalian oocyte maturation. The aim of the current study was to highlight the molecular events triggered by arachidonic acid during oocyte meiotic arrest and resumption at the time of gonadotrophin surge. It should be noted that arachidonic acid release is tightly regulated by Follicle-stimulating and Luteinizing hormones during oocyte development.

Original languageEnglish
JournalBiomedicine and Pharmacotherapy
Pages (from-to)458-467
Number of pages10
Publication statusPublished - 10.2017

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