TY - JOUR
T1 - Potential role of circulating tumor cell detection and monitoring in breast cancer: A review of current evidence
AU - Banys-Paluchowski, Malgorzata
AU - Krawczyk, Natalia
AU - Fehm, Tanja
N1 - Publisher Copyright:
© 2016 Banys-Paluchowski, Krawczyk and Fehm.
PY - 2016
Y1 - 2016
N2 - The phenomenon of hematogenous tumor cell dissemination in patients with solid tumors has been extensively explored over the last decades. Breast cancer research investigated at first disseminated tumor cells in the bone marrow; however, the focus soon moved to circulating tumor cells (CTCs) in the peripheral blood as blood is easily accessible without an invasive procedure. The prognostic significance of CTC presence has been shown in large studies both in adjuvant and metastatic setting and commercially available detection assays have been evaluated for monitoring in clinical trials. Beyond detection and enumeration of CTCs, the characterization of single tumor cells may enhance our knowledge on disease progression and thus optimize treatment choices.
AB - The phenomenon of hematogenous tumor cell dissemination in patients with solid tumors has been extensively explored over the last decades. Breast cancer research investigated at first disseminated tumor cells in the bone marrow; however, the focus soon moved to circulating tumor cells (CTCs) in the peripheral blood as blood is easily accessible without an invasive procedure. The prognostic significance of CTC presence has been shown in large studies both in adjuvant and metastatic setting and commercially available detection assays have been evaluated for monitoring in clinical trials. Beyond detection and enumeration of CTCs, the characterization of single tumor cells may enhance our knowledge on disease progression and thus optimize treatment choices.
UR - http://www.scopus.com/inward/record.url?scp=85009754269&partnerID=8YFLogxK
U2 - 10.3389/fonc.2016.00255
DO - 10.3389/fonc.2016.00255
M3 - Scientific review articles
AN - SCOPUS:85009754269
VL - 6
JO - Frontiers in Oncology
JF - Frontiers in Oncology
SN - 2234-943X
IS - DEC
M1 - 255
ER -