TY - JOUR
T1 - Potential prognostic factors of downstaging following preoperative chemoradiation for high rectal cancer
AU - Treder, Maxi
AU - Vogelsang, Rasmus Peuliche
AU - Janssen, Stefan
AU - Schild, Steven E.
AU - Hollander, Niels Henrik
AU - Rades, Dirk
N1 - Funding Information:
The study was part of the project InnoCan, which is funded by Interreg Deutschland-Danmark with funds from the European Regional Development Fund.
Publisher Copyright:
© 2018 Institute of Electrical and Electronics Engineers Inc. All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Background/Aim: Treatment for high rectal cancers, particularly the value of preoperative treatment, is controversial. In our previous study, downstaging by preoperative chemoradiation resulted in improved outcomes. The aim of the present study was to identify prognostic factors to predict which patients will achieve downstaging and may benefit from preoperative treatment. Patients and Methods: In 54 patients with locally advanced nonmetastatic high rectal cancer, 8 factors were evaluated for downstaging by preoperative chemoradiation including age, gender, carcinoembryonic antigen level, performance status, T-/N-category, UICC-stage (Union for International Cancer Control) and histological grade. Downstaging was defined as decrease by at least one UICC-stage. Results: Downstaging was achieved in 36 patients (67%). Patients at UICC-stage III showed a trend for downstaging. Conclusion: The majority of patients with UICC-stage III tumors were downstaged and appear to benefit from preoperative chemoradiation. In general, the potential value of preoperative treatment for high rectal cancers needs further investigation.
AB - Background/Aim: Treatment for high rectal cancers, particularly the value of preoperative treatment, is controversial. In our previous study, downstaging by preoperative chemoradiation resulted in improved outcomes. The aim of the present study was to identify prognostic factors to predict which patients will achieve downstaging and may benefit from preoperative treatment. Patients and Methods: In 54 patients with locally advanced nonmetastatic high rectal cancer, 8 factors were evaluated for downstaging by preoperative chemoradiation including age, gender, carcinoembryonic antigen level, performance status, T-/N-category, UICC-stage (Union for International Cancer Control) and histological grade. Downstaging was defined as decrease by at least one UICC-stage. Results: Downstaging was achieved in 36 patients (67%). Patients at UICC-stage III showed a trend for downstaging. Conclusion: The majority of patients with UICC-stage III tumors were downstaged and appear to benefit from preoperative chemoradiation. In general, the potential value of preoperative treatment for high rectal cancers needs further investigation.
UR - http://www.scopus.com/inward/record.url?scp=85055151006&partnerID=8YFLogxK
U2 - 10.21873/invivo.11403
DO - 10.21873/invivo.11403
M3 - Journal articles
C2 - 30348705
AN - SCOPUS:85055151006
SN - 0258-851X
VL - 32
SP - 1481
EP - 1484
JO - In Vivo
JF - In Vivo
IS - 6
ER -
