Potential Preventive Strategies for Amyotrophic Lateral Sclerosis

B. Kuraszkiewicz; H. Goszczyńska; T. Podsiadły-Marczykowska; M. Piotrkiewicz; P. Andersen; M. Gromicho; J. Grosskreutz; M. Kuźma-Kozakiewicz; S. Petri; B. Stubbendorf; K. Szacka; H. Uysal; M. de Carvalho

doi:10.3389/fnins.2020.00428

Potential Preventive Strategies for Amyotrophic Lateral Sclerosis

B. Kuraszkiewicz, H. Goszczyńska, T. Podsiadły-Marczykowska, M. Piotrkiewicz^*, P. Andersen, M. Gromicho, J. Grosskreutz, M. Kuźma-Kozakiewicz, S. Petri, B. Stubbendorf, K. Szacka, H. Uysal, M. de Carvalho

^*Corresponding author for this work

9 Citations (Scopus)

Abstract

It may seem useless to propose preventive measures for a disease without established pathogenesis and successful therapy, such as amyotrophic lateral sclerosis (ALS). However, we will show that ALS shares essential molecular mechanisms with aging and that established anti-aging strategies, such as healthy diet or individually adjusted exercise, may be successfully applied to ameliorate the condition of ALS patients. These strategies might be applied for prevention if persons at ALS risk could be identified early enough. Recent research advances indicate that this may happen soon.

Original language	English
Article number	428
Journal	Frontiers in Neuroscience
Volume	14
ISSN	1662-4548
DOIs	https://doi.org/10.3389/fnins.2020.00428
Publication status	Published - 26.05.2020
Externally published	Yes

Funding

This manuscript was partly supported by grant ONWebDUALS No JPND/01/2015 funded by the Polish National Center of Research and Development in frames of EU Joint Program of Neurodegenerative Research.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Centers: Center for Neuromuscular Diseases

Access to Document

10.3389/fnins.2020.00428

Cite this

Kuraszkiewicz, B., Goszczyńska, H., Podsiadły-Marczykowska, T., Piotrkiewicz, M., Andersen, P., Gromicho, M., Grosskreutz, J., Kuźma-Kozakiewicz, M., Petri, S., Stubbendorf, B., Szacka, K., Uysal, H., & de Carvalho, M. (2020). Potential Preventive Strategies for Amyotrophic Lateral Sclerosis. Frontiers in Neuroscience, 14, Article 428. https://doi.org/10.3389/fnins.2020.00428

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abstract = "It may seem useless to propose preventive measures for a disease without established pathogenesis and successful therapy, such as amyotrophic lateral sclerosis (ALS). However, we will show that ALS shares essential molecular mechanisms with aging and that established anti-aging strategies, such as healthy diet or individually adjusted exercise, may be successfully applied to ameliorate the condition of ALS patients. These strategies might be applied for prevention if persons at ALS risk could be identified early enough. Recent research advances indicate that this may happen soon.",

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AU - Goszczyńska, H.

AU - Podsiadły-Marczykowska, T.

AU - Piotrkiewicz, M.

AU - Andersen, P.

AU - Gromicho, M.

AU - Grosskreutz, J.

AU - Kuźma-Kozakiewicz, M.

AU - Petri, S.

AU - Stubbendorf, B.

AU - Szacka, K.

AU - Uysal, H.

AU - de Carvalho, M.

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N2 - It may seem useless to propose preventive measures for a disease without established pathogenesis and successful therapy, such as amyotrophic lateral sclerosis (ALS). However, we will show that ALS shares essential molecular mechanisms with aging and that established anti-aging strategies, such as healthy diet or individually adjusted exercise, may be successfully applied to ameliorate the condition of ALS patients. These strategies might be applied for prevention if persons at ALS risk could be identified early enough. Recent research advances indicate that this may happen soon.

AB - It may seem useless to propose preventive measures for a disease without established pathogenesis and successful therapy, such as amyotrophic lateral sclerosis (ALS). However, we will show that ALS shares essential molecular mechanisms with aging and that established anti-aging strategies, such as healthy diet or individually adjusted exercise, may be successfully applied to ameliorate the condition of ALS patients. These strategies might be applied for prevention if persons at ALS risk could be identified early enough. Recent research advances indicate that this may happen soon.

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M3 - Scientific review articles

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VL - 14

JO - Frontiers in Neuroscience

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M1 - 428

ER -

Potential Preventive Strategies for Amyotrophic Lateral Sclerosis

Abstract

Funding

UN SDGs

Research Areas and Centers

Access to Document

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