Postoperative strahlentherapie beim invasiven mammakarzinom

After primary surgery, radiation therapy is considered an important part of the curative, usually multimodal treatment regimen for patients with locally limited breast cancer. Based on the current results of prospective and randomized studies, its role has been confirmed with a high level of evidence. Radiotherapy following breast-preserving surgery is indispensable for crucial prognostic, local tumor control, which is the most important therapeutic goal. Radiation therapy improves both local disease control and survival. The sequence of radiation and systemic therapies and possible interactions between radiotherapy and new systemic potentially cardiotoxic antineoplastic agents are clinically important, topical questions. Using up-to-date standard irradiation techniques, the cardiotoxicity induced by radiotherapy is considered to be very low. Data on adverse cardiologic interactions of these substances with combined use of percutaneous radiotherapy exist only on a small scale.