Post-Infarction Risk Prediction with Mesh Classification Networks

Marcel Beetz*, Jorge Corral Acero, Abhirup Banerjee, Ingo Eitel, Ernesto Zacur, Torben Lange, Thomas Stiermaier, Ruben Evertz, Sören J. Backhaus, Holger Thiele, Alfonso Bueno-Orovio, Pablo Lamata, Andreas Schuster, Vicente Grau

*Corresponding author for this work

Abstract

Post-myocardial infarction (MI) patients are at risk of major adverse cardiac events (MACE), with risk stratification primarily based on global image-based biomarkers, such as ejection fraction, in current clinical practice. However, these metrics neglect more subtle and localized shape differences in 3D cardiac anatomy and function, which limit predictive accuracy. In this work, we propose a novel geometric deep learning approach to directly predict MACE outcomes within 1 year after the infarction event from high-resolution 3D cardiac anatomy meshes. Its architecture is specifically designed for direct and efficient processing of surface mesh data with a hierarchical, multi-scale structure to enable both local and global feature learning. We evaluate the binary MACE prediction capabilities of the proposed mesh classification network on a multi-center dataset of post-MI patients. Our results show that the proposed method outperforms corresponding clinical benchmarks by ∼ 16% and ∼ 6% in terms of area under the receiver operating characteristic (AUROC) curve for 3D shape and 3D contraction inputs, respectively. Furthermore, we visually analyze both 3D cardiac shapes and 3D contraction patterns with regards to their MACE predictability and demonstrate how task-specific information learned by the network on a balanced dataset successfully generalizes to increasing levels of class imbalance. Finally, we compare our approach to both clinical and machine learning benchmarks on our original highly-imbalanced dataset of post-MI patients and find average improvements in AUROC scores of ∼ 9% and ∼ 3%, respectively.

Original languageEnglish
Title of host publicationStatistical Atlases and Computational Models of the Heart. : Statistical Atlases and Computational Models of the Heart. Regular and CMRxMotion Challenge Papers
EditorsOscar Camara, Esther Puyol-Antón, Chen Qin, Maxime Sermesant, Avan Suinesiaputra, Shuo Wang, Alistair Young
Volume13593
PublisherSpringer
Publication date2023
ISBN (Print)978-3-031-23442-2
ISBN (Electronic)978-3-031-23443-9
DOIs
Publication statusPublished - 2023

Research Areas and Centers

  • Centers: Cardiological Center Luebeck (UHZL)
  • Academic Focus: Biomedical Engineering
  • Centers: Center for Artificial Intelligence Luebeck (ZKIL)

DFG Research Classification Scheme

  • 205-12 Cardiology, Angiology
  • 205-07 Medical Informatics and Medical Bioinformatics

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