Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period

Frieder Schaumburg; Robin Köck; Alexander Mellmann; Laura Richter; Felicitas Hasenberg; André Kriegeskorte; Alexander W. Friedrich; Sören Gatermann; Georg Peters; Christof Von Eiff; Karsten Becker; M. Abele-Horn; F. Albert; A. Anders; W. Bär; B. Beyreiß; G. Bierbaum; U. Bührlen; K. H.U. Borg; C. Diaz; A. Ditzen; M. Dobonici; U. Eigner; H. Erichsen; A. Fahr; P. Finzer; U. Frank; M. Frosch; G. Funke; S. Gatermann; J. Geisen; W. Hell; M. Herrmann; U. Höffler; E. Jacobs; B. Jansen; D. Jonas; M. Kaase; M. Kaulfers; J. K. Knobloch; M. Kresken; B. Körber-Irrgang; M. Van Der Linden; A. Lommel; C. Lücking; D. Mack; S. Müller; L. Von Müller; A. Müller-Chorus; K. Noldt; W. Pfister; T. Regnath; W. Reiter; J. Rissland; A. Roggenkamp; U. Rohr; E. Rosenthal; S. Schade; S. Scherpe; T. Schmidt-Wieland; C. Schoerner; S. Schubert; R. Schwarz; K. Schwegmann; H. Seifert; V. Simon; E. Straube; M. Trautmann; U. Ullmann; U. Vogel; M. Vogt; H. Von Wulffen; T. Wichelhaus; M. L. Wimmer-Dahmen; J. Wüllenweber; B. Würstl; W. Kalka-Moll; S. Monecke; R. R. Reinert; B. Zöllner

doi:10.1128/JCM.01174-12

Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period

Frieder Schaumburg, Robin Köck, Alexander Mellmann, Laura Richter, Felicitas Hasenberg, André Kriegeskorte, Alexander W. Friedrich, Sören Gatermann, Georg Peters, Christof Von Eiff, Karsten Becker^*, M. Abele-Horn, F. Albert, A. Anders, W. Bär, B. Beyreiß, G. Bierbaum, U. Bührlen, K. H.U. Borg, C. DiazA. Ditzen, M. Dobonici, U. Eigner, H. Erichsen, A. Fahr, P. Finzer, U. Frank, M. Frosch, G. Funke, S. Gatermann, J. Geisen, W. Hell, M. Herrmann, U. Höffler, E. Jacobs, B. Jansen, D. Jonas, M. Kaase, M. Kaulfers, J. K. Knobloch, M. Kresken, B. Körber-Irrgang, M. Van Der Linden, A. Lommel, C. Lücking, D. Mack, S. Müller, L. Von Müller, A. Müller-Chorus, K. Noldt, W. Pfister, T. Regnath, W. Reiter, J. Rissland, A. Roggenkamp, U. Rohr, E. Rosenthal, S. Schade, S. Scherpe, T. Schmidt-Wieland, C. Schoerner, S. Schubert, R. Schwarz, K. Schwegmann, H. Seifert, V. Simon, E. Straube, M. Trautmann, U. Ullmann, U. Vogel, M. Vogt, H. Von Wulffen, T. Wichelhaus, M. L. Wimmer-Dahmen, J. Wüllenweber, B. Würstl, W. Kalka-Moll, S. Monecke, R. R. Reinert, B. Zöllner

^*Corresponding author for this work

80 Citations (Scopus)

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) originated from the health care setting but is now emerging in communities without health care contact (CA-MRSA) or in livestock (LA-MRSA). The impact on the whole MRSA population was assessed in a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 MRSA isolates from infection or carriage during two sampling periods in 2004 to 2005 and 2010 to 2011. Patient-related data were collected using a standardized questionnaire. Methicillin resistance was confirmed by the detection of mecA or its homologue mecA_LGA251. The spa type and major virulence factors were analyzed for each isolate. In total, 1,604 (2004 to 2005) and 1,603 (2010 to 2011) MRSA isolates were analyzed; one isolate from each sampling period harbored mecA _LGA251. LA-MRSA increased significantly (odds ratio [OR] = 22.67, 95% confidence interval [CI] = 8.51 to 85.49, P < 0.0005) and spread over Germany, originating from northwestern regions. Panton-Valentine leukocidin-positive CA-MRSA rose significantly, particularly in southern Germany, but the proportion in 2010 to 2011 remained low (2.7%, OR = 2.80, 95% CI = 1.54 to 5.34, P < 0.0005). The emerging MRSA clones changed the MRSA population in Germany during a 6-year period significantly. The ongoing epidemiological shift and changes of MRSA sources create a need for revision of guidelines for MRSA infection control and treatment.

Original language	English
Journal	Journal of Clinical Microbiology
Volume	50
Issue number	10
Pages (from-to)	3186-3192
Number of pages	7
ISSN	0095-1137
DOIs	https://doi.org/10.1128/JCM.01174-12
Publication status	Published - 01.10.2012

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/JCM.01174-12

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Schaumburg, F., Köck, R., Mellmann, A., Richter, L., Hasenberg, F., Kriegeskorte, A., Friedrich, A. W., Gatermann, S., Peters, G., Von Eiff, C., Becker, K., Abele-Horn, M., Albert, F., Anders, A., Bär, W., Beyreiß, B., Bierbaum, G., Bührlen, U., Borg, K. H. U., ... Zöllner, B. (2012). Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period. Journal of Clinical Microbiology, 50(10), 3186-3192. https://doi.org/10.1128/JCM.01174-12

@article{044c01b09ee845209f45c0dc6a155ef2,

title = "Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period",

abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) originated from the health care setting but is now emerging in communities without health care contact (CA-MRSA) or in livestock (LA-MRSA). The impact on the whole MRSA population was assessed in a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 MRSA isolates from infection or carriage during two sampling periods in 2004 to 2005 and 2010 to 2011. Patient-related data were collected using a standardized questionnaire. Methicillin resistance was confirmed by the detection of mecA or its homologue mecALGA251. The spa type and major virulence factors were analyzed for each isolate. In total, 1,604 (2004 to 2005) and 1,603 (2010 to 2011) MRSA isolates were analyzed; one isolate from each sampling period harbored mecA LGA251. LA-MRSA increased significantly (odds ratio [OR] = 22.67, 95% confidence interval [CI] = 8.51 to 85.49, P < 0.0005) and spread over Germany, originating from northwestern regions. Panton-Valentine leukocidin-positive CA-MRSA rose significantly, particularly in southern Germany, but the proportion in 2010 to 2011 remained low (2.7%, OR = 2.80, 95% CI = 1.54 to 5.34, P < 0.0005). The emerging MRSA clones changed the MRSA population in Germany during a 6-year period significantly. The ongoing epidemiological shift and changes of MRSA sources create a need for revision of guidelines for MRSA infection control and treatment.",

author = "Frieder Schaumburg and Robin K{\"o}ck and Alexander Mellmann and Laura Richter and Felicitas Hasenberg and Andr{\'e} Kriegeskorte and Friedrich, {Alexander W.} and S{\"o}ren Gatermann and Georg Peters and {Von Eiff}, Christof and Karsten Becker and M. Abele-Horn and F. Albert and A. Anders and W. B{\"a}r and B. Beyrei{\ss} and G. Bierbaum and U. B{\"u}hrlen and Borg, {K. H.U.} and C. Diaz and A. Ditzen and M. Dobonici and U. Eigner and H. Erichsen and A. Fahr and P. Finzer and U. Frank and M. Frosch and G. Funke and S. Gatermann and J. Geisen and W. Hell and M. Herrmann and U. H{\"o}ffler and E. Jacobs and B. Jansen and D. Jonas and M. Kaase and M. Kaulfers and Knobloch, {J. K.} and M. Kresken and B. K{\"o}rber-Irrgang and {Van Der Linden}, M. and A. Lommel and C. L{\"u}cking and D. Mack and S. M{\"u}ller and {Von M{\"u}ller}, L. and A. M{\"u}ller-Chorus and K. Noldt and W. Pfister and T. Regnath and W. Reiter and J. Rissland and A. Roggenkamp and U. Rohr and E. Rosenthal and S. Schade and S. Scherpe and T. Schmidt-Wieland and C. Schoerner and S. Schubert and R. Schwarz and K. Schwegmann and H. Seifert and V. Simon and E. Straube and M. Trautmann and U. Ullmann and U. Vogel and M. Vogt and {Von Wulffen}, H. and T. Wichelhaus and Wimmer-Dahmen, {M. L.} and J. W{\"u}llenweber and B. W{\"u}rstl and W. Kalka-Moll and S. Monecke and Reinert, {R. R.} and B. Z{\"o}llner",

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language = "English",

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pages = "3186--3192",

journal = "Journal of Clinical Microbiology",

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Schaumburg, F, Köck, R, Mellmann, A, Richter, L, Hasenberg, F, Kriegeskorte, A, Friedrich, AW, Gatermann, S, Peters, G, Von Eiff, C, Becker, K, Abele-Horn, M, Albert, F, Anders, A, Bär, W, Beyreiß, B, Bierbaum, G, Bührlen, U, Borg, KHU, Diaz, C, Ditzen, A, Dobonici, M, Eigner, U, Erichsen, H, Fahr, A, Finzer, P, Frank, U, Frosch, M, Funke, G, Gatermann, S, Geisen, J, Hell, W, Herrmann, M, Höffler, U, Jacobs, E, Jansen, B, Jonas, D, Kaase, M, Kaulfers, M, Knobloch, JK, Kresken, M, Körber-Irrgang, B, Van Der Linden, M, Lommel, A, Lücking, C, Mack, D, Müller, S, Von Müller, L, Müller-Chorus, A, Noldt, K, Pfister, W, Regnath, T, Reiter, W, Rissland, J, Roggenkamp, A, Rohr, U, Rosenthal, E, Schade, S, Scherpe, S, Schmidt-Wieland, T, Schoerner, C, Schubert, S, Schwarz, R, Schwegmann, K, Seifert, H, Simon, V, Straube, E, Trautmann, M, Ullmann, U, Vogel, U, Vogt, M, Von Wulffen, H, Wichelhaus, T, Wimmer-Dahmen, ML, Wüllenweber, J, Würstl, B, Kalka-Moll, W, Monecke, S, Reinert, RR & Zöllner, B 2012, 'Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period', Journal of Clinical Microbiology, vol. 50, no. 10, pp. 3186-3192. https://doi.org/10.1128/JCM.01174-12

TY - JOUR

T1 - Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period

AU - Schaumburg, Frieder

AU - Köck, Robin

AU - Mellmann, Alexander

AU - Richter, Laura

AU - Hasenberg, Felicitas

AU - Kriegeskorte, André

AU - Friedrich, Alexander W.

AU - Gatermann, Sören

AU - Peters, Georg

AU - Von Eiff, Christof

AU - Becker, Karsten

AU - Abele-Horn, M.

AU - Albert, F.

AU - Anders, A.

AU - Bär, W.

AU - Beyreiß, B.

AU - Bierbaum, G.

AU - Bührlen, U.

AU - Borg, K. H.U.

AU - Diaz, C.

AU - Ditzen, A.

AU - Dobonici, M.

AU - Eigner, U.

AU - Erichsen, H.

AU - Fahr, A.

AU - Finzer, P.

AU - Frank, U.

AU - Frosch, M.

AU - Funke, G.

AU - Gatermann, S.

AU - Geisen, J.

AU - Hell, W.

AU - Herrmann, M.

AU - Höffler, U.

AU - Jacobs, E.

AU - Jansen, B.

AU - Jonas, D.

AU - Kaase, M.

AU - Kaulfers, M.

AU - Knobloch, J. K.

AU - Kresken, M.

AU - Körber-Irrgang, B.

AU - Van Der Linden, M.

AU - Lommel, A.

AU - Lücking, C.

AU - Mack, D.

AU - Müller, S.

AU - Von Müller, L.

AU - Müller-Chorus, A.

AU - Noldt, K.

AU - Pfister, W.

AU - Regnath, T.

AU - Reiter, W.

AU - Rissland, J.

AU - Roggenkamp, A.

AU - Rohr, U.

AU - Rosenthal, E.

AU - Schade, S.

AU - Scherpe, S.

AU - Schmidt-Wieland, T.

AU - Schoerner, C.

AU - Schubert, S.

AU - Schwarz, R.

AU - Schwegmann, K.

AU - Seifert, H.

AU - Simon, V.

AU - Straube, E.

AU - Trautmann, M.

AU - Ullmann, U.

AU - Vogel, U.

AU - Vogt, M.

AU - Von Wulffen, H.

AU - Wichelhaus, T.

AU - Wimmer-Dahmen, M. L.

AU - Wüllenweber, J.

AU - Würstl, B.

AU - Kalka-Moll, W.

AU - Monecke, S.

AU - Reinert, R. R.

AU - Zöllner, B.

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Methicillin-resistant Staphylococcus aureus (MRSA) originated from the health care setting but is now emerging in communities without health care contact (CA-MRSA) or in livestock (LA-MRSA). The impact on the whole MRSA population was assessed in a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 MRSA isolates from infection or carriage during two sampling periods in 2004 to 2005 and 2010 to 2011. Patient-related data were collected using a standardized questionnaire. Methicillin resistance was confirmed by the detection of mecA or its homologue mecALGA251. The spa type and major virulence factors were analyzed for each isolate. In total, 1,604 (2004 to 2005) and 1,603 (2010 to 2011) MRSA isolates were analyzed; one isolate from each sampling period harbored mecA LGA251. LA-MRSA increased significantly (odds ratio [OR] = 22.67, 95% confidence interval [CI] = 8.51 to 85.49, P < 0.0005) and spread over Germany, originating from northwestern regions. Panton-Valentine leukocidin-positive CA-MRSA rose significantly, particularly in southern Germany, but the proportion in 2010 to 2011 remained low (2.7%, OR = 2.80, 95% CI = 1.54 to 5.34, P < 0.0005). The emerging MRSA clones changed the MRSA population in Germany during a 6-year period significantly. The ongoing epidemiological shift and changes of MRSA sources create a need for revision of guidelines for MRSA infection control and treatment.

AB - Methicillin-resistant Staphylococcus aureus (MRSA) originated from the health care setting but is now emerging in communities without health care contact (CA-MRSA) or in livestock (LA-MRSA). The impact on the whole MRSA population was assessed in a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 MRSA isolates from infection or carriage during two sampling periods in 2004 to 2005 and 2010 to 2011. Patient-related data were collected using a standardized questionnaire. Methicillin resistance was confirmed by the detection of mecA or its homologue mecALGA251. The spa type and major virulence factors were analyzed for each isolate. In total, 1,604 (2004 to 2005) and 1,603 (2010 to 2011) MRSA isolates were analyzed; one isolate from each sampling period harbored mecA LGA251. LA-MRSA increased significantly (odds ratio [OR] = 22.67, 95% confidence interval [CI] = 8.51 to 85.49, P < 0.0005) and spread over Germany, originating from northwestern regions. Panton-Valentine leukocidin-positive CA-MRSA rose significantly, particularly in southern Germany, but the proportion in 2010 to 2011 remained low (2.7%, OR = 2.80, 95% CI = 1.54 to 5.34, P < 0.0005). The emerging MRSA clones changed the MRSA population in Germany during a 6-year period significantly. The ongoing epidemiological shift and changes of MRSA sources create a need for revision of guidelines for MRSA infection control and treatment.

UR - http://www.scopus.com/inward/record.url?scp=84866443733&partnerID=8YFLogxK

U2 - 10.1128/JCM.01174-12

DO - 10.1128/JCM.01174-12

M3 - Journal articles

C2 - 22814464

AN - SCOPUS:84866443733

SN - 0095-1137

VL - 50

SP - 3186

EP - 3192

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 10

ER -

Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period

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