Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period

Frieder Schaumburg, Robin Köck, Alexander Mellmann, Laura Richter, Felicitas Hasenberg, André Kriegeskorte, Alexander W. Friedrich, Sören Gatermann, Georg Peters, Christof Von Eiff, Karsten Becker*, M. Abele-Horn, F. Albert, A. Anders, W. Bär, B. Beyreiß, G. Bierbaum, U. Bührlen, K. H.U. Borg, C. DiazA. Ditzen, M. Dobonici, U. Eigner, H. Erichsen, A. Fahr, P. Finzer, U. Frank, M. Frosch, G. Funke, S. Gatermann, J. Geisen, W. Hell, M. Herrmann, U. Höffler, E. Jacobs, B. Jansen, D. Jonas, M. Kaase, M. Kaulfers, J. K. Knobloch, M. Kresken, B. Körber-Irrgang, M. Van Der Linden, A. Lommel, C. Lücking, D. Mack, S. Müller, L. Von Müller, A. Müller-Chorus, K. Noldt, W. Pfister, T. Regnath, W. Reiter, J. Rissland, A. Roggenkamp, U. Rohr, E. Rosenthal, S. Schade, S. Scherpe, T. Schmidt-Wieland, C. Schoerner, S. Schubert, R. Schwarz, K. Schwegmann, H. Seifert, V. Simon, E. Straube, M. Trautmann, U. Ullmann, U. Vogel, M. Vogt, H. Von Wulffen, T. Wichelhaus, M. L. Wimmer-Dahmen, J. Wüllenweber, B. Würstl, W. Kalka-Moll, S. Monecke, R. R. Reinert, B. Zöllner

*Corresponding author for this work
80 Citations (Scopus)


Methicillin-resistant Staphylococcus aureus (MRSA) originated from the health care setting but is now emerging in communities without health care contact (CA-MRSA) or in livestock (LA-MRSA). The impact on the whole MRSA population was assessed in a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 MRSA isolates from infection or carriage during two sampling periods in 2004 to 2005 and 2010 to 2011. Patient-related data were collected using a standardized questionnaire. Methicillin resistance was confirmed by the detection of mecA or its homologue mecALGA251. The spa type and major virulence factors were analyzed for each isolate. In total, 1,604 (2004 to 2005) and 1,603 (2010 to 2011) MRSA isolates were analyzed; one isolate from each sampling period harbored mecA LGA251. LA-MRSA increased significantly (odds ratio [OR] = 22.67, 95% confidence interval [CI] = 8.51 to 85.49, P < 0.0005) and spread over Germany, originating from northwestern regions. Panton-Valentine leukocidin-positive CA-MRSA rose significantly, particularly in southern Germany, but the proportion in 2010 to 2011 remained low (2.7%, OR = 2.80, 95% CI = 1.54 to 5.34, P < 0.0005). The emerging MRSA clones changed the MRSA population in Germany during a 6-year period significantly. The ongoing epidemiological shift and changes of MRSA sources create a need for revision of guidelines for MRSA infection control and treatment.

Original languageEnglish
JournalJournal of Clinical Microbiology
Issue number10
Pages (from-to)3186-3192
Number of pages7
Publication statusPublished - 01.10.2012

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


Dive into the research topics of 'Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period'. Together they form a unique fingerprint.

Cite this