Polymorphisms of the prion protein gene (PRNP) in a Serbian population

Rajna Dimitrijević, Ivana Čadež, Milica Keckarević-Marković, Dušan Keckarević, Miljana Kecmanović, Valerija Dobričić, Dušanka Savić-Pavićević, Goran Brajušković, Stanka Romac


Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.

Original languageEnglish
JournalInternational Journal of Neuroscience
Issue number7
Pages (from-to)496-501
Number of pages6
Publication statusPublished - 05.2010


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