Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis

Beate Mascher; Wilhelm Schmitt; Elena Csernok; Efstratios Tatsis; Angelika Reil; Wolfgang L. Gross; Michael Seyfarth

Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis

Beate Mascher^*, Wilhelm Schmitt, Elena Csernok, Efstratios Tatsis, Angelika Reil, Wolfgang L. Gross, Michael Seyfarth

^*Corresponding author for this work

Abstract

Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-α gene at position -308, the second in the first intron of the TNF-β gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).

Original language	English
Journal	Experimental and Clinical Immunogenetics
Volume	14
Issue number	3
Pages (from-to)	226-233
Number of pages	8
ISSN	0254-9670
Publication status	Published - 01.1998

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title = "Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis",

abstract = "Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-α gene at position -308, the second in the first intron of the TNF-β gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).",

author = "Beate Mascher and Wilhelm Schmitt and Elena Csernok and Efstratios Tatsis and Angelika Reil and Gross, {Wolfgang L.} and Michael Seyfarth",

year = "1998",

month = jan,

language = "English",

volume = "14",

pages = "226--233",

journal = "Experimental and Clinical Immunogenetics",

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TY - JOUR

T1 - Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis

AU - Mascher, Beate

AU - Schmitt, Wilhelm

AU - Csernok, Elena

AU - Tatsis, Efstratios

AU - Reil, Angelika

AU - Gross, Wolfgang L.

AU - Seyfarth, Michael

PY - 1998/1

Y1 - 1998/1

N2 - Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-α gene at position -308, the second in the first intron of the TNF-β gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).

AB - Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-α gene at position -308, the second in the first intron of the TNF-β gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).

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M3 - Journal articles

C2 - 9493791

AN - SCOPUS:6844240852

SN - 0254-9670

VL - 14

SP - 226

EP - 233

JO - Experimental and Clinical Immunogenetics

JF - Experimental and Clinical Immunogenetics

IS - 3

ER -

Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis

Abstract

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