Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis

Beate Mascher*, Wilhelm Schmitt, Elena Csernok, Efstratios Tatsis, Angelika Reil, Wolfgang L. Gross, Michael Seyfarth

*Corresponding author for this work
23 Citations (Scopus)


Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-α gene at position -308, the second in the first intron of the TNF-β gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).

Original languageEnglish
JournalExperimental and Clinical Immunogenetics
Issue number3
Pages (from-to)226-233
Number of pages8
Publication statusPublished - 01.1998


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