Polymorphisms in the renin-angiotensin system and outcome of very-low-birthweight infants

J. Spiegler; A. Gilhaus; I. R. König; E. Kattner; M. Vochem; H. Küster; J. Möller; D. Müller; A. Kribs; H. Segerer; C. Wieg; W. Nikischin; A. Von Der Wense; C. Gebauer; E. Herting; W. Göpel

doi:10.1159/000226602

Polymorphisms in the renin-angiotensin system and outcome of very-low-birthweight infants

J. Spiegler^*, A. Gilhaus, I. R. König, E. Kattner, M. Vochem, H. Küster, J. Möller, D. Müller, A. Kribs, H. Segerer, C. Wieg, W. Nikischin, A. Von Der Wense, C. Gebauer, E. Herting, W. Göpel

^*Corresponding author for this work

25 Citations (Scopus)

Abstract

Background: The insertion/deletion polymorphism of the angiotensin- converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. Objective: To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. Method: Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. Results: There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus. Conclusion: Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.

Original language	English
Journal	Neonatology
Volume	97
Issue number	1
Pages (from-to)	10-14
Number of pages	5
ISSN	1661-7800
DOIs	https://doi.org/10.1159/000226602
Publication status	Published - 01.2009

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1159/000226602

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Spiegler, J., Gilhaus, A., König, I. R., Kattner, E., Vochem, M., Küster, H., Möller, J., Müller, D., Kribs, A., Segerer, H., Wieg, C., Nikischin, W., Von Der Wense, A., Gebauer, C., Herting, E., & Göpel, W. (2009). Polymorphisms in the renin-angiotensin system and outcome of very-low-birthweight infants. Neonatology, 97(1), 10-14. https://doi.org/10.1159/000226602

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title = "Polymorphisms in the renin-angiotensin system and outcome of very-low-birthweight infants",

abstract = "Background: The insertion/deletion polymorphism of the angiotensin- converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. Objective: To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. Method: Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. Results: There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus. Conclusion: Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.",

author = "J. Spiegler and A. Gilhaus and K{\"o}nig, \{I. R.\} and E. Kattner and M. Vochem and H. K{\"u}ster and J. M{\"o}ller and D. M{\"u}ller and A. Kribs and H. Segerer and C. Wieg and W. Nikischin and \{Von Der Wense\}, A. and C. Gebauer and E. Herting and W. G{\"o}pel",

year = "2009",

month = jan,

doi = "10.1159/000226602",

language = "English",

volume = "97",

pages = "10--14",

journal = "Neonatology",

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TY - JOUR

T1 - Polymorphisms in the renin-angiotensin system and outcome of very-low-birthweight infants

AU - Spiegler, J.

AU - Gilhaus, A.

AU - König, I. R.

AU - Kattner, E.

AU - Vochem, M.

AU - Küster, H.

AU - Möller, J.

AU - Müller, D.

AU - Kribs, A.

AU - Segerer, H.

AU - Wieg, C.

AU - Nikischin, W.

AU - Von Der Wense, A.

AU - Gebauer, C.

AU - Herting, E.

AU - Göpel, W.

PY - 2009/1

Y1 - 2009/1

N2 - Background: The insertion/deletion polymorphism of the angiotensin- converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. Objective: To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. Method: Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. Results: There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus. Conclusion: Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.

AB - Background: The insertion/deletion polymorphism of the angiotensin- converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. Objective: To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. Method: Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. Results: There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus. Conclusion: Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.

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DO - 10.1159/000226602

M3 - Journal articles

C2 - 19571582

AN - SCOPUS:67649418108

SN - 1661-7800

VL - 97

SP - 10

EP - 14

JO - Neonatology

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IS - 1

ER -

Polymorphisms in the renin-angiotensin system and outcome of very-low-birthweight infants

Abstract

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