TY - JOUR
T1 - Polymorphisms in the renin-angiotensin system and outcome of very-low-birthweight infants
AU - Spiegler, J.
AU - Gilhaus, A.
AU - König, I. R.
AU - Kattner, E.
AU - Vochem, M.
AU - Küster, H.
AU - Möller, J.
AU - Müller, D.
AU - Kribs, A.
AU - Segerer, H.
AU - Wieg, C.
AU - Nikischin, W.
AU - Von Der Wense, A.
AU - Gebauer, C.
AU - Herting, E.
AU - Göpel, W.
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2009/1
Y1 - 2009/1
N2 - Background: The insertion/deletion polymorphism of the angiotensin- converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. Objective: To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. Method: Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. Results: There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus. Conclusion: Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.
AB - Background: The insertion/deletion polymorphism of the angiotensin- converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. Objective: To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. Method: Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. Results: There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus. Conclusion: Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.
UR - http://www.scopus.com/inward/record.url?scp=67649418108&partnerID=8YFLogxK
U2 - 10.1159/000226602
DO - 10.1159/000226602
M3 - Journal articles
C2 - 19571582
AN - SCOPUS:67649418108
SN - 1661-7800
VL - 97
SP - 10
EP - 14
JO - Neonatology
JF - Neonatology
IS - 1
ER -