Polymorphism in murine mtATP8 gene correlates with decreased reactive oxygen species in aging hematopoietic cells

Catrin Roolf, Christin Kretzschmar, Katrin Timmer, Anett Sekora, Gudrun Knübel, Hugo Murua Escobar, Georg Fuellen, Saleh M. Ibrahim, Markus Tiedge, Simone Baltrusch, Sarah Müller, Rüdiger Köhling, Christian Junghanss*

*Corresponding author for this work
1 Citation (Scopus)

Abstract

Background: Mitochondrial DNA (mtDNA) encodes for the respiratory chain proteins. Genetic alterations in mtDNA have been described during aging and linked to impaired hematopoiesis. Materials and Methods: We investigated two novel conplastic mouse strains harboring a mitochondrial nt7778 G/T polymorphism leading to an amino acid exchange in respiratory chain complex V. Effects on reactive oxygen species (ROS) and adenosine triphosphate (ATP) levels, as well as bone marrow composition and peripheral blood counts, were investigated during aging (up to 24 month). Results: The polymorphism correlated with significantly decreased ROS levels in aged mice. Effects on hematopoiesis were marginal and not statistically significant: numbers of erythroid cells in bone marrow, as well as mean corpuscular hemoglobin, tended to decrease over time. Conclusion: The investigated polymorphism is associated with decreased ROS levels in aged hematopoietic cells but does not significantly influence hematopoiesis itself.

Original languageEnglish
JournalIn Vivo
Volume30
Issue number6
Pages (from-to)751-760
Number of pages10
ISSN0258-851X
DOIs
Publication statusPublished - 01.11.2016

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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