Translated title of the contribution: Polyclonal B-cell activation by immuno-augmentation

J. Kekow, G. Hobusch, J. Ludemann, W. L. Gross

1 Citation (Scopus)


Immuno-augmentation with substances of bacterial orogin was studied in vitro for its ability to induce polyclonal B-cell activation. Biostim®, Broncho-Vaxom®, Omnadin®, Paspat® and OK 432 were compared for their B-cell mitogenicity with classical polyclonal B-cell activators (Stah. aureus Cowan I, KlebsM, Pokeweed mitogen). B-cell mitogenicity, as measured by 3H-thymidine incorporation into proliferating blood B-cells, was not induced by any of the studied preparations. On the other hand, OK 432 produced a T-cell dependent and Biostim a T-cell independent blood B-cell differentiation in immunoglobulin producing cells. However, the extent of immunoglobulin production was clearly less than with the polyclonal B-cell activator KlebsM. These results demonstrate that, in some of the preparations, in vivo polyclonal B-cell activation can be expected to occur.

Translated title of the contributionPolyclonal B-cell activation by immuno-augmentation
Original languageGerman
JournalDeutsche Medizinische Wochenschrift
Issue number28-29
Pages (from-to)1101-1106
Number of pages6
Publication statusPublished - 1989

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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