Abstract
Genetic analysis of the polar body can be a suitable approach for preimplantation genetic diagnosis of certain monogenic disorders and maternal structural chromosomal aberrations. Because most numerical chromosomal abnormalities originate from female meiosis it has also been suggested that polar body testing might be used to increases the efficiency of assisted reproduction techniques by positive selection of euploid oocytes for further in-vitro culture and transfer in the womb. Since the chance of meiotic errors in oocytes increases with age, aneuploidy screening in polar body analysis has mostly been performed for women with increased maternal age.
| Translated title of the contribution | Polar body diagnosis from the point of view of reproductive medicine |
|---|---|
| Original language | German |
| Journal | Medizinische Genetik |
| Volume | 16 |
| Issue number | 4 |
| Pages (from-to) | 393-397 |
| Number of pages | 5 |
| ISSN | 0936-5931 |
| Publication status | Published - 12.2004 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
DFG Research Classification Scheme
- 2.22-21 Gynaecology and Obstetrics
- 2.22-23 Reproductive Medicine, Urology
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