TY - JOUR
T1 - Pituitary gland volume in at-risk mental state for psychosis
T2 - A longitudinal MRI analysis
AU - Walter, Anna
AU - Studerus, Erich
AU - Smieskova, Renata
AU - Tamagni, Corinne
AU - Rapp, Charlotte
AU - Borgwardt, Stefan J.
AU - Riecher-Rössler, Anita
N1 - Publisher Copyright:
Copyright © Cambridge University Press 2014.
PY - 2015/2/26
Y1 - 2015/2/26
N2 - Introduction. Pituitary enlargement has been reported in individuals with schizophrenic psychosis or an at-risk mental state for psychosis (ARMS). In a previous study, our group could show pituitary volume increase in first episode and ARMS patients with later transition to psychosis (ARMS-T). However, there are no longitudinal studies on this issue so far. We therefore examined longitudinally whether transition to psychosis would be accompanied by a further increase of pituitary volume in antipsychotic-naïve ARMS patients. Methods. Magnetic resonance imaging (MRI) data were acquired from 23 antipsychotic-naïve individuals with an ARMS. Ten subjects developed psychosis (ARMS-T) and 13 did not (ARMS-NT). ARMS-T were re-scanned after the onset of psychosis, and ARMS-NT were re-scanned at the end of the study period. Results. There was no significant difference of the pituitary volume between ARMS-T and ARMS-NT in our sample, and there were no significant pituitary volume changes over time. Discussion. Longitudinally, we could not detect any further volumetric changes in the pituitary volume with transition to psychosis. Conclusions. This, together with the result of our previous study, could indicate that the perceived level of stress in ARMS patients is constantly high from very early onward.
AB - Introduction. Pituitary enlargement has been reported in individuals with schizophrenic psychosis or an at-risk mental state for psychosis (ARMS). In a previous study, our group could show pituitary volume increase in first episode and ARMS patients with later transition to psychosis (ARMS-T). However, there are no longitudinal studies on this issue so far. We therefore examined longitudinally whether transition to psychosis would be accompanied by a further increase of pituitary volume in antipsychotic-naïve ARMS patients. Methods. Magnetic resonance imaging (MRI) data were acquired from 23 antipsychotic-naïve individuals with an ARMS. Ten subjects developed psychosis (ARMS-T) and 13 did not (ARMS-NT). ARMS-T were re-scanned after the onset of psychosis, and ARMS-NT were re-scanned at the end of the study period. Results. There was no significant difference of the pituitary volume between ARMS-T and ARMS-NT in our sample, and there were no significant pituitary volume changes over time. Discussion. Longitudinally, we could not detect any further volumetric changes in the pituitary volume with transition to psychosis. Conclusions. This, together with the result of our previous study, could indicate that the perceived level of stress in ARMS patients is constantly high from very early onward.
UR - http://www.scopus.com/inward/record.url?scp=84918801142&partnerID=8YFLogxK
U2 - 10.1017/S109285291400011X
DO - 10.1017/S109285291400011X
M3 - Journal articles
C2 - 24618395
AN - SCOPUS:84918801142
SN - 1092-8529
VL - 20
SP - 122
EP - 129
JO - CNS Spectrums
JF - CNS Spectrums
IS - 2
ER -